Secondary CIC‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report
| Autor: | Hironobu Minami, Yoshinori Imamura, Hidetomo Takakura, Sakuya Matsumoto, Maki Kanzawa, Yohei Funakoshi, Shiro Kimbara, Teruya Kawamoto, Masanori Toyoda, Taiji Koyama, Takanori Hirose, Yoshimi Fujishima, Hitomi Hara, Naomi Kiyota |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment chemotherapy Malignancy etoposide secondary sarcoma 03 medical and health sciences 0302 clinical medicine CIC-rearranged sarcoma Internal medicine medicine Anaplastic large-cell lymphoma Etoposide Ewing-like sarcoma Chemotherapy Ifosfamide ifosfamide business.industry Standard treatment Cancer Articles medicine.disease 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Sarcoma business medicine.drug |
| Zdroj: | Molecular and Clinical Oncology |
| ISSN: | 2049-9469 2049-9450 |
| Popis: | Capicua transcriptional repressor (CIC)-rearranged sarcoma is an Ewing-like sarcoma with an aggressive clinical course and poor prognosis. No standard treatment has been established. The present study describes a case of CIC-rearranged sarcoma with lung metastases developing in a 24-year-old woman as a therapy-associated malignancy following chemotherapy for anaplastic large cell lymphoma at nine years old. This was treated with palliative regimens used for Ewing sarcoma. The patient achieved disease control for one year. Of note, ifosfamide and etoposide (IE), which were used as a second line treatment lead to a partial response. The case described in the present study indicated that treatment with Ewing regimens is a reasonable option for patients with metastatic CIC-rearranged sarcoma, including those with a second malignant case. |
| Databáze: | OpenAIRE |
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