Mucosal vaccination against diphtheria using starch microparticles as adjuvant for cross-reacting material (CRM197) of diphtheria toxin
| Autor: | Ingvar Sjöholm, Niclas Rydell |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_treatment
Administration Oral Biology Mice Immune system Bacterial Proteins Immunity medicine Animals Diphtheria Toxin Immunity Mucosal Diphtheria toxin Mice Inbred BALB C General Veterinary General Immunology and Microbiology Diphtheria Vaccination Public Health Environmental and Occupational Health Starch Immunoglobulin E medicine.disease Antibodies Bacterial Infectious Diseases Immunization Immunoglobulin G Immunology Molecular Medicine Female Nasal administration sense organs Adjuvant |
| Zdroj: | Vaccine. 23:2775-2783 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2004.11.049 |
| Popis: | Mucosal vaccination has the advantage of eliciting a local mucosal immune response as well as a systemic response. In this investigation, polyacryl starch microparticles were conjugated to diphtheria toxin cross-reacting material (CRM197) as a mucosal adjuvant for oral or intranasal immunisation of mice. Various methods of stabilising CRM197 with formaldehyde were investigated. A good systemic and local mucosal immune response was attained with oral immunisation when CRM197 was treated with a relatively low formaldehyde concentration prior to conjugation to the microparticles. No immune response was seen after intranasal immunisation. |
| Databáze: | OpenAIRE |
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