Ethical Considerations in Screening for Rapid Eye Movement Sleep Behavior Disorder in the General Population
| Autor: | Eline M. Bunnik, Annemarie I. Luik, Lisanne J. Dommershuijsen, Brenda C.T. Kieboom, Sirwan K.L. Darweesh, Peter J. Koudstaal, M. Kamran Ikram, M. Arfan Ikram, Agnita J.W. Boon |
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| Přispěvatelé: | Epidemiology, Neurology, Public Health |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Synucleinopathies education Population Rapid eye movement sleep REM Sleep Behavior Disorder Disease REM sleep behavior disorder Prodromal phase 03 medical and health sciences Behavior disorder Rotterdam Study 0302 clinical medicine medicine Humans Psychiatry education.field_of_study business.industry Parkinson Disease medicine.disease 030104 developmental biology Neurology Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Movement Disorders, 35(11), 1939-1944. John Wiley & Sons Inc. |
| ISSN: | 1531-8257 0885-3185 |
| DOI: | 10.1002/mds.28262 |
| Popis: | Clinical studies have shown that up to 90% of patients with idiopathic rapid eye movement sleep behavior disorder (RBD) will eventually be diagnosed with a clinical α-synucleinopathy. Because of this high conversion rate, screening for RBD is often performed to identify eligible participants for studies aimed at elucidating the prodromal phase of α-synucleinopathies. However, screening for RBD, especially in the general population, raises many ethical dilemmas. In light of the existing ethical literature and our experience in establishing a screening approach for RBD in the Rotterdam Study, we discuss ethical dilemmas when screening for RBD in population-based studies. We conclude that informing study participants about the reason for invitation and the possible trajectory that lies ahead when participating is essential. However, participants should not be troubled unnecessarily by giving them detailed information about possible diagnoses or associated disease risks. © 2020 International Parkinson and Movement Disorder Society. |
| Databáze: | OpenAIRE |
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