Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists

Autor:	Bernice L. Brogdon, Michael Koblish, Christopher T. Saeui, Bertrand Le Bourdonnec, Roland E. Dolle, Damian G. Weaver, Allan J. Goodman, Karin Worm, Joel A. Cassel, Robert N. DeHaven, Robert L. Broadrup, Steve Smith, Christopher J. LaBuda, Guo-Hua Chu
Rok vydání:	2009
Předmět:	Agonist Male Cannabinoid receptor medicine.drug_class Stereochemistry Pyridines medicine.medical_treatment Morpholines Clinical Biochemistry Pharmaceutical Science Administration Oral Aminopyridines Pain Carboxamide Biochemistry Chemical synthesis Rats Sprague-Dawley Receptor Cannabinoid CB2 Structure-Activity Relationship Dogs Receptor Cannabinoid CB1 In vivo Drug Discovery medicine Structure–activity relationship Animals Humans Molecular Biology Chemistry Organic Chemistry Cannabinoid Receptor Agonists Rats Microsomes Liver Molecular Medicine lipids (amino acids peptides and proteins) Cannabinoid Protein Binding
Zdroj:	Bioorganicmedicinal chemistry letters. 19(20)
ISSN:	1464-3405
Popis:	Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92190c9dee633d84b4e95697f96c3099 https://pubmed.ncbi.nlm.nih.gov/19736007 Zobrazit plný text záznamu Full Text from ScienceDirect