Increased glutathione-S-transferase activity in antioxidant-deficient rats
| Autor: | William L. Stone, Edward A. Dratz |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Biophysics chemistry.chemical_element Biochemistry Retina Lipid peroxidation Selenium chemistry.chemical_compound In vivo Selenium deficiency Testis medicine Animals Vitamin E Deficiency Enzyme inducer Molecular Biology Glutathione Transferase chemistry.chemical_classification biology Vitamin E Brain medicine.disease Rats Enzyme Liver chemistry Enzyme Induction biology.protein |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 631:503-506 |
| ISSN: | 0304-4165 |
| Popis: | Rats fed a diet deficient in vitamin E and selenium show an increased activity of glutathione-S-transferase (EC 2.5.1.18) in all tissues tested, with the possible exception of the retina. Glutathione-S-transferases are detoxifying enzymes that are induced by a variety of electrophilic drugs or toxins. Therefore, the induction of glutathione-S-transferase in vitamine E- and selenium-deficient rats indicates that substrates for the enzyme probably increase in vivo with dietary antioxidant deficiency. These substrates are likely to be lipid peroxides and/or other lipid peroxidation products. |
| Databáze: | OpenAIRE |
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