Antihypertensive drug utilization and conformity to guidelines in a sub-Saharan African hypertensive population
| Autor: | Ademola Aderibigbe, T O Olanrewaju, Emmanuel O Sanya, Olusegun Adesola Busari |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Angiotensin receptor medicine.medical_specialty medicine.drug_class Cross-sectional study Population Nigeria Blood Pressure Pharmacology Internal medicine medicine Humans Pharmacology (medical) Methyldopa Practice Patterns Physicians' Medical prescription Hospitals Teaching Antihypertensive drug education Antihypertensive Agents Aged Aged 80 and over education.field_of_study biology business.industry Angiotensin-converting enzyme Middle Aged Cross-Sectional Studies Blood pressure Hypertension Practice Guidelines as Topic biology.protein Female Guideline Adherence business Follow-Up Studies medicine.drug |
| Zdroj: | Int. Journal of Clinical Pharmacology and Therapeutics. 48:68-75 |
| ISSN: | 0946-1965 |
| DOI: | 10.5414/cpp48068 |
| Popis: | Background: Despite avail- ability and usage of wide array of antihyper- tensive drugs, blood pressure has remained poorly controlled in most health care settings particularly in Africa. The cost of these drugs among other factors strongly determines the prescription and usage pattern which ulti- mately affects control of blood pressure par- ticularly in sub-Saharan Africa. The aim of this study was to describe the current utiliza- tion pattern of antihypertensive drugs in a ter- tiary hospital in Nigeria in line with the re- gional and international guidelines for hyper- tension management and to compare with similar studies in other parts of the country to generate the national outlook. Methods: This is a cross sectional study of 805 adult hyper- tensive patients who were on treatment at the Medical Out-Patient Department of Univer- sity of Ilorin Teaching Hospital in Nigeria, a country with the most populous black hyper- tensive patients. Data were collated from the patients' records and evaluated according to drug classifications. Results: 787 patients out of the 805 evaluated were eventually in- cluded in the analysis. Mean age was 57.88 ± 12.59 years with 490 (62.3%) females. Fre- quency of use of classes of antihypertensive was: diuretics (D, 84%), calcium channel blockers (CCB, 66%), angiotensin convert- ing enzyme inhibitors (ACEI, 65%), -methyldopa (ALD, 26%), beta-blockers (BB, 11.9%) and angiotensin receptor blockers (3.8%). Proportions of number of drugs usage per patient were: 0 (2.2%), 1 (9.1%), 2 (37.1%), 3 (35.8%), 4 (15.6%), and 5 (0.1%). The most commonly used combina- tions of drugs were ACEI + CCB + D (21.6%), followed by CCB + D (14.5%), ACE + D (11.4%) and ACEI + D + ALD (9.8%). Other recent studies in Nigeria re- vealed diuretics and multiple agents as the prevalent prescription pattern. Conclusion: Antihypertensive utilization in Ilorin, Nigeria like some parts of the country conforms to the guidelines for the management of hyperten- sion in blacks with majority of patients on di- uretics particularly in combination with other agents. Angiotensin converting enzyme in- hibitors are increasingly being used whereas beta-blockers and angiotensin receptor antag- onists are still less utilized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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