Role of Voltage-Dependent Calcium Channel Long-Term Potentiation (LTP) and NMDA LTP in Spatial Memory
| Autor: | Harlan M. Fichtenholtz, Brian L. Woodside, Timothy J. Teyler, Albert M. Borroni |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_treatment Period (gene) Long-Term Potentiation Spatial Behavior Pharmacology Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley Memory medicine Animals ARTICLE Maze Learning Saline Behavior Animal Voltage-dependent calcium channel Working memory General Neuroscience Retention Psychology Long-term potentiation Calcium Channel Blockers Rats Blockade Verapamil NMDA receptor Calcium Channels Dizocilpine Maleate Psychology Excitatory Amino Acid Antagonists Neuroscience medicine.drug |
| Zdroj: | The Journal of Neuroscience. 20:9272-9276 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.20-24-09272.2000 |
| Popis: | This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 d period, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr). |
| Databáze: | OpenAIRE |
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