Erosions in the foot at baseline are predictive of orthopaedic shoe use after 10 years of treat to target therapy in patients with recent onset rheumatoid arthritis
| Autor: | Pit J S M Kerstens, Cornelia F Allaart, H. Karel Ronday, K. Huub Han, Rosaline van den Berg, Robert Landewé, Willem F. Lems, I.M. Markusse, Sytske Anne Bergstra, G. Akdemir |
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| Přispěvatelé: | Rheumatology, MOVE Research Institute, AII - Inflammatory diseases, Clinical Immunology and Rheumatology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male musculoskeletal diseases 030506 rehabilitation medicine.medical_specialty Orthotic Devices Logistic regression Severity of Illness Index Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Foot Joints medicine otorhinolaryngologic diseases Humans In patient Rheumatoid arthritis Recent onset Orthopaedic shoes Aged Netherlands 030203 arthritis & rheumatology business.industry Brief Report Treat to target General Medicine Middle Aged medicine.disease Prognosis Shoes body regions Logistic Models Risk factors Antirheumatic Agents Orthopedic surgery Multivariate Analysis Physical therapy Disease Progression Female 0305 other medical science business Erosions Foot (unit) Follow-Up Studies |
| Zdroj: | Clinical Rheumatology, 35(8):35: 2101, 2101-2107. Springer London Clinical Rheumatology Clinical Rheumatology, 35(8), 2101-2107 Clinical rheumatology, 35(8), 2101-2107. Springer London Bergstra, S A, Markusse, I M, Akdemir, G, Ronday, H K, Han, K H, Lems, W F, Kerstens, P J S M, van den Berg, R, Landewe, R B M & Allaart, C F 2016, ' Erosions in the foot at baseline are predictive of orthopaedic shoe use after 10 years of treat to target therapy in patients with recent onset rheumatoid arthritis ', Clinical Rheumatology, vol. 35, no. 8, 35: 2101, pp. 2101-2107 . https://doi.org/10.1007/s10067-015-3145-1 |
| ISSN: | 0770-3198 |
| DOI: | 10.1007/s10067-015-3145-1 |
| Popis: | The objective of this study is to investigate if foot joint damage due to rheumatoid arthritis (RA) can predict whether patients will start wearing orthopaedic shoes (OS) within 10 years after treatment start. Data from recent onset RA patients with 10 years follow-up from the BeSt (Dutch acronym for treatment strategies) study were used. Treatment was tightly controlled, targeted at disease activity score (DAS) ≤2.4, according to 1 of 4 pre-specified treatment strategies. After 10 years of follow-up, orthopaedic shoe use was recorded in 285/508 patients (responders to questionnaires at 10 years). Between-group differences for orthopaedic shoe users and non-users were calculated at baseline, after 10 years, and change scores over the 10-year period were calculated. Predictors for orthopaedic shoe use were identified by univariable and multivariable logistic regression analyses. Orthopaedic shoe use was reported by 57/285 patients after 10 years. Orthopaedic shoe users had more joint damage, joint swelling and pain in the feet already at baseline and after 10 years. At both time points, DAS of orthopaedic shoe users and non-users was similar. Multivariable logistic regression showed that dichotomized foot erosions score (cut-off ≥1 erosion) (OR 2.42), anti-citrullinated protein antibodies (ACPA) (OR 4.64) and DAS (OR 1.77) were independent predictors of orthopaedic shoe use. Despite intensive targeted treatment, 57/285 recent onset RA patients started using orthopaedic shoes over 10 year of follow-up. Presence of foot erosions at treatment start predicts orthopaedic shoe use after 10 years. The risk of orthopedic shoe use increased for ACPA-positive patients and for those with higher baseline disease activity. Electronic supplementary material The online version of this article (doi:10.1007/s10067-015-3145-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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