Alexithymia, suicide ideation and homocysteine levels in drug naïve patients with major depression: a study in the real world clinical practice
| Autor: | Massimo Di Giannantonio, Paola Annunziata Varasano, Domenico De Berardis, Nicola Serroni, Michele Fornaro, Serena Di Natale, Laura Orsolini, Alessandro Carano, Giovanni Martinotti, F. Vellante, Luigi Olivieri, Gabriella Rapini, Maurizio Pompili, Gabriella Lucidi Pressanti, Gianluca Serafini, Alessandro Valchera |
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| Přispěvatelé: | De Berardis, D., Olivieri, L., Rapini, G., Di Natale, S., Serroni, N., Fornaro, M., Orsolini, L., Valchera, A., Carano, A., Vellante, F., Varasano, P. A., Pressanti, G. L., Serafini, G., Pompili, M., Martinotti, G., Di Giannantonio, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Alexithymia
Homocysteine Affective symptom 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Toronto Alexithymia Scale 0302 clinical medicine Rating scale Suicidal ideation medicine Pharmacology (medical) Depression (differential diagnoses) Affective symptoms medicine.diagnostic_test business.industry Depression Brief Report medicine.disease 030227 psychiatry Psychiatry and Mental health Drug-naïve chemistry Major depressive disorder medicine.symptom business 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| Popis: | Objective : This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naive outpatients with major depressive disorder (MDD). Methods : Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation, and homocysteine levels. Results : Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20' "Difficulty in Describing Feelings" dimension, in turn being associated with higher suicide ideation. Conclusion : In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression' severity. However, study limitations are discussed and must be considered. |
| Databáze: | OpenAIRE |
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