Palliative Local Radiotherapy for Advanced Squamous Cell Carcinoma of the Head-and-Neck: Prognostic Factors of Survival
| Autor: | Karl L Bruchhage, Julika Ribbat-Idel, Christian Idel, Sven Perner, Dirk Rades, Steven E. Schild, Samer G. Hakim, Christian Staackmann |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Multivariate analysis medicine.medical_treatment Systemic therapy Palliative radiotherapy Internal medicine Humans Medicine Basal cell Stage (cooking) Retrospective Studies Univariate analysis Radiotherapy Squamous Cell Carcinoma of Head and Neck business.industry Palliative Care Cancer General Medicine Prognosis medicine.disease Survival Analysis Radiation therapy Head and Neck Neoplasms business |
| Zdroj: | Anticancer Research. 41:3205-3210 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15107 |
| Popis: | BACKGROUND/AIM A considerable number of patients with advanced head-and-neck cancer (SCCHN) receive palliative radiotherapy. This study aimed to identify prognostic factors for survival to facilitate personalized treatment for these patients. PATIENTS AND METHODS Ninety-two patients receiving palliative radiotherapy for SCCHN were retrospectively analyzed. Fourteen characteristics were evaluated for survival including age, gender, performance score, pre-radiotherapy hemoglobin, tumor site and stage, histologic grade, p16-status, equivalent dose in 2 Gy-fractions (EQD2), completion of radiotherapy, upfront surgery and systemic therapy. RESULTS On univariate analysis, improved survival was significantly associated with pre-radiotherapy hemoglobin ≥12 g/dl (p=0.003), EQD2 >42.3 Gy (p=0.003) and completion of radiotherapy (p |
| Databáze: | OpenAIRE |
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