Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China

Autor: Ting Ting Chen, Helen S. Bond, Zi Feng Yang, Zheng Tu Li, J S Malik Peiris, Yuan Chen, Benjamin J. Cowling, Ya Sha Luo, Yu Lam Siu, Huiying Chua, Ying Liang, Wen Da Guan, Si Hua Pan, Yongping Lin, Jimmy C. C. Lai, Chris Ka PunMok
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Antibodies
Viral
Influenza A Virus
H7N9 Subtype
medicine.disease_cause
Serology
0302 clinical medicine
Medical microbiology
Seroepidemiologic Studies
030212 general & internal medicine
Child
Public health
education.field_of_study
Antibody titer
Middle Aged
3. Good health
Titer
Infectious Diseases
Child
Preschool
Population Surveillance
Female
Erratum
Adult
China
medicine.medical_specialty
Adolescent
Population
Avian influenza A(H7N9)
Severity
Virus
lcsh:Infectious and parasitic diseases
Birds
Young Adult
03 medical and health sciences
Influenza
Human
medicine
Animals
Humans
Seroprevalence
lcsh:RC109-216
education
Aged
business.industry
Infant
Newborn
Infant
Hemagglutination Inhibition Tests
Virology
Influenza A virus subtype H5N1
030104 developmental biology
Influenza in Birds
business
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-6 (2016)
ISSN: 1471-2334
DOI: 10.1186/s12879-016-1983-3
Popis: BACKGROUND: Since the identification in early 2013 of severe disease caused by influenza A(H7N9) virus infection, there have been few attempts to characterize the full severity profile of human infections. Our objective was to estimate the number and severity of H7N9 infections in Guangzhou, using a serological study. METHODS: We collected residual sera from patients of all ages admitted to a hospital in the city of Guangzhou in southern China in 2013 and 2014. We screened the sera using a haemagglutination inhibition assay against a pseudovirus containing the H7 and N9 of A/Anhui/1/2013(H7N9), and samples with a screening titer ≥10 were further tested by standard hemagglutination-inhibition and virus neutralization assays for influenza A(H7N9). We used a statistical model to interpret the information on antibody titers in the residual sera, assuming that the residual sera provided a representative picture of A(H7N9) infections in the general population, accounting for potential cross-reactions. RESULTS: We collected a total of 5360 residual sera from December 2013 to April 2014 and from October 2014 to December 2014, and found two specimens that tested positive for H7N9 antibody at haemagglutination inhibition titer ≥40 and a neutralization titer ≥40. Based on this, we estimated that 64,000 (95 % credibility interval: 7300, 190,000) human infections with influenza A(H7N9) virus occurred in Guangzhou in early 2014, with an infection-fatality risk of 3.6 deaths (95 % credibility interval: 0.47, 15) per 10,000 infections. CONCLUSIONS: Our study suggested that the number of influenza A(H7N9) virus infections in Guangzhou substantially exceeded the number of laboratory-confirmed cases there, albeit with considerable imprecision. Our study was limited by the small number of positive specimens identified, and larger serologic studies would be valuable. Our analytic framework would be useful if larger serologic studies are done.
published_or_final_version
Databáze: OpenAIRE
Externí odkaz: