Chronic alcohol consumption, type 2 diabetes mellitus, insulin-like growth factor-I (IGF-I), and growth hormone (GH) in ethanol-treated diabetic rats

Autor: Soo-Jeong Kim, Seul-Gi Lim, Anes Ju, Daijin Kim
Rok vydání: 2013
Předmět:
Blood Glucose
Male
medicine.medical_specialty
OLETF rats
Alcohol Drinking
Rats
Inbred OLETF
medicine.medical_treatment
Carbohydrate metabolism
General Biochemistry
Genetics and Molecular Biology
Impaired glucose tolerance
Pharmacology
Toxicology and Pharmaceutics(all)
Insulin-like growth factor
Internal medicine
Glucose Intolerance
medicine
Animals
Insulin
Insulin-Like Growth Factor I
General Pharmacology
Toxicology and Pharmaceutics
Glucose tolerance test
Ethanol
medicine.diagnostic_test
Biochemistry
Genetics and Molecular Biology(all)
business.industry
Growth factor
Body Weight
Type 2 Diabetes Mellitus
Glucose tolerance
General Medicine
Glucose Tolerance Test
medicine.disease
IGF-I
Rats
Endocrinology
Diabetes Mellitus
Type 2
Growth Hormone
Metabolic control analysis
LETO rats
Alcohol use
business
Zdroj: Life Sciences. 93:778-782
ISSN: 0024-3205
Popis: Aims Alcohol has deleterious influences on glucose metabolism which may contribute to the development of type 2 diabetes mellitus (T2DM). Insulin-like growth factor I (IGF-I) and growth hormone (GH), which interact with insulin to modulate metabolic control, have been shown to be related to impaired glucose tolerance. This study was conducted to assess the possibility that altered circulating IGF-I and GH levels contribute to the exacerbation of T2DM by alcohol use in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic Long-Evans Tokushima Otsuka (LETO) rats. Main method OLETF rats were pair-fed a Lieber-DeCarli Regular Ethanol diet and LETO rats were pair-fed a control diet for 6 weeks. At 6 weeks, an Intraperitoneal Glucose Tolerance Test (IP-GTT) was performed and IGF-I and GH levels were evaluated. Key findings Prior to an IP-GTT, OLETF-Ethanol (O-E) group had significantly a decrease in the mean glucose levels compared to OLETF-Control (O-C) group. At 120 min post IP-GTT, the O-E group had significantly an increase in the mean glucose levels compared to O-C group. The serum IGF-I levels were significantly lower and the serum GH levels were significantly higher in the O-E group than in L-C group. Significance These results suggest that IGF-I and GH are prominent in defining the risk and development of T2DM, and may be adversely affected by heavy alcohol use, possibly mediating its diabetogenic effects. Thus, the overall glucose intolerance in the setting of alcoholism may be attributable to inappropriate alteration of IGF-I and GH levels.
Databáze: OpenAIRE
Externí odkaz: