NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status
| Autor: | W.-I. Yang, Seung Sook Lee, S.-W. Kim, E-Y Cho, C.-W. Kim, H.-K. Chang, H. J. Ree, J.-E. Kim, Young Hyeh Ko, J.-R. Huh |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Herpesvirus 4 Human Histology Adolescent Perforation (oil well) Soft Tissue Neoplasms medicine.disease_cause Poly(A)-Binding Proteins Pathology and Forensic Medicine Natural killer cell Necrosis Testicular Neoplasms hemic and lymphatic diseases medicine Gammaherpesvirinae T-cell lymphoma Humans In Situ Hybridization Aged Gastrointestinal Neoplasms Aged 80 and over Gene Rearrangement biology T-cell receptor Lymphoma T-Cell Peripheral Proteins RNA-Binding Proteins General Medicine Gene rearrangement Middle Aged biology.organism_classification medicine.disease Prognosis Epstein–Barr virus Survival Analysis CD56 Antigen Lymphoma Parotid Neoplasms T-Cell Intracellular Antigen-1 Killer Cells Natural medicine.anatomical_structure Head and Neck Neoplasms RNA Viral Female |
| Zdroj: | Histopathology. 44(5) |
| ISSN: | 0309-0167 |
| Popis: | Aims: To analyse the clinicopathological findings of extranasal CD56+ cytotoxic T- or NK-cell lymphomas in different organs and to compare Epstein–Barr virus (EBV)+ and EBV– lymphoma of non-blastoid cytomorphology. Methods and results: Fifty-one cases of cCD3+ T-cell intracellular antigen (TIA-1)+ CD56+ lymphomas of extranodal/extranasal origin were included in the study. The primary sites of the CD56+ tumours were soft tissue (n = 10), the gastrointestinal (GI) tract (n = 13), the skin (n = 15), upper aerodigestive tract excluding nasal and nasopharyngeal regions (n = 11), the testis (n = 1), and parotid gland (n = 1). TCR gene rearrangement was detected in seven of 47 cases examined (16%). EBV was positive in 39 of 51 cases (76%). The positive rate of EBV was higher in tumours of soft tissue (80%), GI tract (92%), and skin (80%), and lowest in the upper aerodigestive tract excluding the nasal and nasopharyngeal region (50%). Tumours of the soft tissue and the upper aerodigestive tract tended to present with localized disease (P = 0.002). The 2-year survival rate was lowest for tumours of the GI tract (P = 0.0256). EBV– TCR– lymphoma showed less necrosis (P = 0.0133) and a better 2-year survival rate (P = 0.0066) than EBV+ TCR– lymphoma. Patients with EBV+ TCR+ lymphomas tended to present with localized disease, more often than EBV+ TCR– lymphoma (P = 0.0186). Significant prognostic factors in all CD56+ lymphomas were the site (P = 0.0256), EBV status (P = 0.0026), necrosis with or without perforation (P = 0.0338) and the presence of pleomorphic large tumour cells (P = 0.0428). Cox's regression analysis adjusting for other pathological parameters showed EBV status to be the only independent prognostic factor (P = 0.018). Conclusions: Extranodal CD56+ EBV– lymphoma at extranasal sites is a clinically less aggressive malignancy and displays less necrosis than CD56+ EBV+ lymphoma. Because CD56+ EBV+ TCR+ lymphomas show similar pathological and clinical findings to CD56+ EBV+ TCR– lymphomas, nasal-type NK/T-cell lymphomas at extranasal sites should be diagnosed as such on the basis of EBV+, cytotoxic T or NK phenotype irrespective of the genotype determined by molecular study. |
| Databáze: | OpenAIRE |
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