Exploiting the Redox Activity of MIL-100(Fe) Carrier Enables Prolonged Carvacrol Antimicrobial Activity

Autor: Katia Caamaño, Raquel Heras-Mozos, Joaquín Calbo, Jesús Cases Díaz, João C. Waerenborgh, Bruno J. C. Vieira, Pilar Hernández-Muñoz, Rafael Gavara, Mónica Giménez-Marqués
Přispěvatelé: Ministerio de Ciencia e Innovación (España), European Commission, Generalitat Valenciana
Rok vydání: 2022
Předmět:
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Caamaño, Katia Heras-Mozos, Raquel Calbo Roig, Joaquín Cases Díaz, Jesús Waerenborgh, João C. Vieira, Bruno J. C. Hernández Muñoz, Pilar Gavara Clemente, Rafael Giménez Marqués, Mónica 2022 Exploiting the Redox Activity of MIL-100(Fe) Carrier Enables Prolonged Carvacrol Antimicrobial Activity Acs Applied Materials & Interfaces 14 8 10758 10768
Katia Caamaño, Raquel Heras-Mozos, Joaquín Calbo, Jesús Cases Díaz, João C. Waerenborgh, Bruno J. C. Vieira, Pilar Hernández-Muñoz, Rafael Gavara, and Mónica Giménez-Marqués (2022). Exploiting the Redox Activity of MIL-100(Fe) Carrier Enables Prolonged Carvacrol Antimicrobial Activity. ACS Applied Materials & Interfaces, 14 (8), 10758-10768.
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Popis: The design of efficient food contact materials that maintain optimal levels of food safety is of paramount relevance to reduce the increasing number of foodborne illnesses. In this work, we develop a smart composite metal-organic framework (MOF)-based material that fosters a unique prolonged antibacterial activity. The composite is obtained by entrapping a natural food preserving molecule, carvacrol, into a mesoporous MIL-100(Fe) material following a direct and biocompatible impregnation method, and obtaining particularly high payloads. By exploiting the intrinsic redox nature of the MIL-100(Fe) material, it is possible to achieve a prolonged activity against Escherichia coli and Listeria innocua due to a triggered two-step carvacrol release from films containing the carvacrol@MOF composite. Essentially, it was discovered that based on the underlying chemical interaction between MIL-100(Fe) and carvacrol, it is possible to undergo a reversible charge-transfer process between the metallic MOF counterpart and carvacrol upon certain chemical stimuli. During this process, the preferred carvacrol binding site was monitored by infrared, Mössbauer, and electron paramagnetic resonance spectroscopies, and the results are supported by theoretical calculations.
The authors acknowledge funding from MCIN/AEI/10.13039/501100011033 (grants PID2020-118564GA-I00, PID2020-119748GA-I00, and CEX2019-000919-M, grants RTI2018-093452-B-I00 and PRE2018-083355 included in Project MAT2017-89993-R funded by “ERDF A way of making Europe”, and grant BES-2016-077380 funded by “ESF Investing in your future”) and from Generalitat Valenciana (SEJI2020/036 and GV/2021/027). M.G.M. thanks MICIN for a “Ramón y Cajal (RYC2019-027902-I). IST authors acknowledge FCT (Portugal) support through contracts UID/Multi/04349/2019 and PTDC/QUI-QIN/32240/2017.
Databáze: OpenAIRE
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