Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities
| Autor: | Willem J. G. Melchers, Ruud L.M. Bekkers, R P de Bie, J.A. de Hullu, Albert G. Siebers, Johan Bulten, Leon F A G Massuger, H.P. van de Nieuwenhof |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty usual vulvar intraepithelial neoplasia Vulvar Squamous Cell Carcinoma Uterine Cervical Neoplasms Aetiology screening and detection [ONCOL 5] Alphapapillomavirus Quality of Care [ONCOL 4] Translational research [ONCOL 3] Clinical Studies medicine Carcinoma Humans Risk factor human papillomavirus Vulvar Diseases Aged Gynecology Aged 80 and over Vaginal Smears Vulvar Neoplasms Hereditary cancer and cancer-related syndromes [ONCOL 1] integumentary system business.industry urogenital system vulvar squamous cell carcinoma Papillomavirus Infections Cancer cervical high-grade squamous intraepithelial lesion Vulvar cancer Middle Aged Vulvar intraepithelial neoplasia medicine.disease Uterine Cervical Dysplasia Dermatology female genital diseases and pregnancy complications Pathogenesis and modulation of inflammation [N4i 1] Squamous intraepithelial lesion Human Reproduction [NCEBP 12] stomatognathic diseases Oncology Carcinoma Squamous Cell Female business Precancerous Conditions Infection and autoimmunity [NCMLS 1] Carcinoma in Situ |
| Zdroj: | British Journal of Cancer, 101, 27-31 British Journal of Cancer, 101, 1, pp. 27-31 British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Contains fulltext : 81890.pdf (Publisher’s version ) (Closed access) BACKGROUND: Vulvar squamous cell carcinoma (SCC) originates the following two pathways, related to differentiated (d) vulvar intraepithelial neoplasia (VIN) or to human papillomavirus (HPV)-related usual (u) VIN. Multicentric HPV infections (cervix, vagina and vulva) are common. We hypothesise that patients with a uVIN-related vulvar SCC more often have cervical high-grade squamous intraepithelial lesions (HSILs) compared with women with dVIN-related vulvar SCC. METHODS: All vulvar SCCs (201) were classified to be dVIN- (n=164) or uVIN related (n=37). Data with regard to the smear history and cervical histology were retrieved from PALGA, the nationwide Netherlands database of histo- and cytopathology. For HSIL cervical smears of which histology was taken, HPV DNA analysis on both the vulvar and cervical specimens was performed. RESULTS: At least one smear was available in 145 (72%) of the 201 patients. Patients with a uVIN-related vulvar SCC more often had an HSIL compared with patients with a dVIN-related SCC (35 vs 2%, P |
| Databáze: | OpenAIRE |
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