3D multi-scale, multi-task, and multi-label deep learning for prediction of lymph node metastasis in T1 lung adenocarcinoma patients' CT images
Autor: | Zhen Li, Jiayi Zhang, Shiyuan Liu, Xiang Wang, Xin Gao, Rui Zhang, Yechen Zhu, Yuguo Tang, Junming Jian, Xingyu Zhao, Wei Xia |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Lung Neoplasms Computer science Health Informatics Adenocarcinoma of Lung Metastasis Deep Learning medicine Humans Radiology Nuclear Medicine and imaging Segmentation Medical diagnosis Lymph node Interpretability Radiological and Ultrasound Technology business.industry Deep learning medicine.disease Computer Graphics and Computer-Aided Design Confidence interval medicine.anatomical_structure Lymphatic Metastasis Adenocarcinoma Computer Vision and Pattern Recognition Radiology Artificial intelligence business Tomography X-Ray Computed |
Zdroj: | Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. 93 |
ISSN: | 1879-0771 |
Popis: | The diagnosis of preoperative lymph node (LN) metastasis is crucial to evaluate possible therapy options for T1 lung adenocarcinoma patients. Radiologists preoperatively diagnose LN metastasis by evaluating signs related to LN metastasis, like spiculation or lobulation of pulmonary nodules in CT images. However, this type of evaluation is subjective and time-consuming, which may result in poor consistency and low efficiency of diagnoses. In this study, a 3D Multi-scale, Multi-task, and Multi-label classification network (3M‐CN) was proposed to predict LN metastasis, as well as evaluate multiple related signs of pulmonary nodules in order to improve the accuracy of LN metastasis prediction. The following key approaches were adapted for this method. First, a multi-scale feature fusion module was proposed to aggregate the features from different levels for which different labels be best modeled at different levels; second, an auxiliary segmentation task was applied to force the model to focus more on the nodule region and less on surrounding unrelated structures; and third, a cross-modal integration module called the refine layer was designed to integrate the related risk factors into the model to further improve its confidence level. The 3M‐CN was trained using data from 401 cases and then validated on both internal and external datasets, which consisted of 100 cases and 53 cases, respectively. The proposed 3M‐CN model was then compared with existing state-of-the-art methods for prediction of LN metastasis. The proposed model outperformed other methods, achieving the best performance with AUCs of 0.945 and 0.948 in the internal and external test datasets, respectively. The proposed model not only obtain strong generalization, but greatly enhance the interpretability of the deep learning model, increase doctors' confidence in the model results, conform to doctors' diagnostic process, and may also be transferable to the diagnosis of other diseases. |
Databáze: | OpenAIRE |
Externí odkaz: |