Delta-CHr improves the identification of anemic syndromes and the evaluation of hemoglobin synthesis
| Autor: | P. Vicinanza, Bruno Rotoli, M. Vicinanza, Lucio Catalano, A. De Renzo, M. Buonanno, Giuditta Pollio, P. Di Chiara |
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| Rok vydání: | 2005 |
| Předmět: |
Erythrocyte Indices
Male medicine.medical_specialty Reticulocytes Microcytic anemia Clinical Biochemistry Macrocytosis Sensitivity and Specificity Reduced hemoglobin Hemoglobins Reticulocyte Internal medicine medicine Humans Anemia Iron-Deficiency business.industry Biochemistry (medical) Hemoglobin synthesis Hematology General Medicine medicine.disease medicine.anatomical_structure Endocrinology Reference values Erythropoiesis Female Hemoglobin business |
| Zdroj: | Clinical and laboratory haematology. 27(4) |
| ISSN: | 0141-9854 |
| Popis: | Reticulocyte hemoglobin content (CHr) is considered an index of iron status, helpful in the differential diagnosis of microcytoses. Its potential can be enhanced by comparing CHr dynamic reference values (CHr-e: expected CHr), which are proportional to the MCVr variations occurring in micro- or macrocytosis, with measured CHr values. We demonstrate that the difference between measured CHr and CHr-e (DeltaCHr) is helpful to differentiate the anemic syndromes and, in particular, beta-thalassemia vs. presumable sideropenia. DeltaCHr can also indicate when to interrupt iron supplementation. DeltaCHr allows an insight into the erythropoiesis of thalassemic and sideropenic subjects, pointing out the reduced hemoglobin production and ineffective erythroid activity in these conditions. |
| Databáze: | OpenAIRE |
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