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Obesity is a chronic low-grade inflammatory state that is related to prediabetes, increased Rhoassociated kinase 2 (ROCK2) activity and concentration of high-sensitivity C-reactive protein (hs-CRP). Therefore, the study was conducted to investigate the effects of 12-week moderate aerobic exercise on ROCK2 activity, hs-CRP, glycosylated hemoglobin A1C (HbA1c), and glycemic index in obese patients with impaired glucose tolerance.In a quasi-experimental design with pre and post-test, 42 obese men with prediabetes [mean±SD, age: 44.73 ± 3.30 years, body mass index (BMI): 33.22 ± 2.05 kg/msup2/sup, HbA1c: 6.29% ± 0.75] were allocated into two randomized homogeneous groups: Aerobic training group (AT, n = 22) or control group (C, n = 20). Exercise group performed a moderate aerobic exercise program three sessions per week, 60 min per session for 12 weeks. Body mass, BMI, maximal oxygen consumption (VOsub2/submax), serum levels of fasting blood glucose (FBG), insulin, insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-B); HbA1c, hs-CRP, or ROCK2 activity were measured before and after the study period. The data were analyzed using repeated measures ANOVA 2 × 2 and paired sample t-test at a significant level of plt; 0.05.AT caused a significant reduction in body mass (p ≤ 0.001), BMI (p = 0.04), HOMA-B (p = 0.003), serum levels of FBG (p = 0.002), HbA1c (p = 0.039), hs-CRP (p ≤ 0.0001), and ROCK2 activity (p = 0.001). In contrast, in the same group, a significant increase was observed in VOsub2/submax (p = 0.04).The results of this study showed that moderate aerobic exercise was an effective and safe method to prevent type 2 diabetes and cardiovascular diseases in obese men with prediabetes by improving glucose metabolism, reduction of body mass, ROCK2 activity and serum levels of hs-CRP. |
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