Antigoitrogenic Properties of Some 3′-Alkyl-iodothyronines

Autor:	Marvin S. Wool, Herbert A. Selenkow, Victor S. Fang
Rok vydání:	1966
Předmět:	chemistry.chemical_classification medicine.medical_specialty Diiodothyronines Biochemical Phenomena Goiter Pharmacology Biochemistry Effective dose (pharmacology) Rats Endocrinology chemistry Internal medicine Thyronines medicine Animals Triiodothyronine Potency High activity Female Alkyl ED50
Zdroj:	Endocrinology. 78:29-33
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-78-1-29
Popis:	The thyromimetic activities of several 3′-alkyl-3,5-diiodothyronines were studied by the rat antigoitrogenic assay and compared with L-T3 and L-T4. L-3′-Isopropyl- 3,5-diiodothyronine was the most potent member of this series. On an equimolar basis, this remarkable compound had twice the activity of L-T3 with a 50% effective dose (ED50) of 0.07 compared to 0.13 μg/day for L-T3. Its 5′-iodinated derivative was somewhat less potent than L-T3, with an ED50 of 0.25 μg/day, but was more active than L-T4 (ED50 1.2 μg/day). DL-3′-Ethyl-diiodothyronine (ED50 0.25 μg/day) had a potency between that of L-T3 and L-T4. L-3′-Isobutyl-diiodothyronine (ED50 1.5 μg/day) was less active than L-T4. These synthetic thyroxine analogs exhibit unusually high activity and are of particular interest in that they represent the first group of 3′ non-halogen-substituted diiodothyronines to have significant thyromimetic properties. (Endocrinology 78:29, 1966)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ffa9231f309f165c11f8f6a601d288 https://doi.org/10.1210/endo-78-1-29 Zobrazit plný text záznamu