Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH‐mediated Pleural Photodynamic Therapy (pPDT)
| Autor: | Andreea Dimofte, Xing Liang, Theresa M. Busch, Michele M. Kim, Keith A. Cengel, Joseph S. Friedberg, Charles B. Simone, Jarod C. Finlay, Eli Glatstein, Timothy C. Zhu, Yi Hong Ong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chlorophyll
Materials science Infrared Rays Point source Pleural Neoplasms medicine.medical_treatment Photodynamic therapy 01 natural sciences Biochemistry Fluence Article 03 medical and health sciences 0302 clinical medicine 0103 physical sciences medicine Humans Distribution (pharmacology) Physical and Theoretical Chemistry 010306 general physics Detector Navigation system General Medicine Factor method Photochemotherapy 030220 oncology & carcinogenesis Surface contour Biomedical engineering |
| Zdroj: | Photochem Photobiol |
| ISSN: | 1751-1097 0031-8655 |
| Popis: | Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcomes. However, current practice when delivering intrapleural PDT uses a point source to deliver light that is monitored by seven isotropic detectors placed within the pleural cavity to assess its uniformity. We have developed a real-time infrared (IR) tracking camera to follow the movement of the light point source and the surface contour of the treatment area. The calculated light fluence rates were matched with isotropic detectors using a two-correction factor method and an empirical model that includes both direct and scattered light components. Our clinical trial demonstrated that we can successfully implement the IR navigation system in 75% (15/20) of the patients. Data were successfully analyzed in 80% (12/15) patients because detector locations were not available for three patients. We conclude that it is feasible to use an IR camera-based system to track the motion of the light source during PDT and demonstrate its use to quantify the uniformity of light distribution, which deviated by a standard deviation of 18% from the prescribed light dose. The navigation system will fail when insufficient percentage of light source positions is obtained ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text