| Autor: |
Mengjing Wang, Qianqian Li, Changzhi Shi, Jia Lv, Youdong Xu, Junjie Yang, Shae Linn Chua, Linran Jia, Huaiwen Chen, Qian Liu, Changjin Huang, Yichao Huang, Jianmin Chen, Mingliang Fang |
| Přispěvatelé: |
School of Civil and Environmental Engineering, School of Materials Science and Engineering, School of Mechanical and Aerospace Engineering |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
The health risks of exposure to 'eco-friendly' biodegradable plastics of anthropogenic origin and their effects on the gastrointestinal tract are largely unknown. Here we demonstrate that the enzymatic hydrolysis of polylactic acid microplastics generated nanoplastic particles by competing for triglyceride-degrading lipase during gastrointestinal processes. Nanoparticle oligomers were formed by hydrophobically driven self-aggregation. In a mouse model, polylactic acid oligomers and their nanoparticles bioaccumulated in the liver, intestine and brain. Hydrolysed oligomers caused intestinal damage and acute inflammation. A large-scale pharmacophore model revealed that oligomers interacted with matrix metallopeptidase 12. Mechanistically, high binding affinity (Kd = 13.3 μmol l-1) of oligomers to the catalytic zinc-ion finger domain led to matrix metallopeptidase 12 inactivation, which might mediate the adverse bowel inflammatory effects after exposure to polylactic acid oligomers. Biodegradable plastics are considered to be a solution to address environmental plastic pollution. Thus, understanding the gastrointestinal fates and toxicities of bioplastics will provide insights into potential health risks. Ministry of Education (MOE) This work was primarily supported by the National Key R&D Program (nos. 2022YFC3702600 and 2022YFC3702601), the Singapore Ministry of Education Academic Research Fund Tier 1 (04MNP000567C120), the Ministry of Science and Technology of China (2022YF3701101), Startup Grant of Fudan University (no. JIH 1829010Y), Education Department of Anhui Province for Excellent Young Scientist (2022AH030076) and Second Tibetan Plateau Scientific Expedition and Research program (2019QZKK0682). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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