Serum Caspase-1 levels in women with polycystic ovary syndrome
| Autor: | Cihan Kabukçu, Ozer Oztekin, Yasar Enli, Semin Fenkci, Ümit Çabuş, Veysel Fenkci, Vildan Caner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Caspase-1 IL-10 PCOS Insulin resistance Oxidative stress cholesterol blood level IL10 protein human lipid blood level Androgen Excess medicine.disease_cause low density lipoprotein cholesterol hyperandrogenism interleukin 1beta converting enzyme chemistry.chemical_compound 0302 clinical medicine high density lipoprotein cholesterol homeostasis model assessment insulin resistance triacylglycerol level Malondialdehyde oxidative stress Insulin glucose glutathione clinical article 030219 obstetrics & reproductive medicine adult Caspase 1 malonaldehyde Obstetrics and Gynecology Fasting Polycystic ovary Interleukin-10 female Androgens triacylglycerol medicine.symptom diet restriction Polycystic Ovary Syndrome medicine.medical_specialty Inflammation androgen lcsh:Gynecology and obstetrics Article 03 medical and health sciences assessment of humans blood Internal medicine ovary polycystic disease medicine Humans controlled study human gonadotropin lcsh:RG1-991 controlled clinical trial Free androgen index business.industry dyslipidemia case control study medicine.disease glucose blood level Endocrinology chemistry Case-Control Studies testosterone interleukin 10 luteinizing hormone blood level free androgen index business Gonadotropins Hormone |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 59, Iss 2, Pp 207-210 (2020) |
| ISSN: | 1028-4559 |
| Popis: | Objective: Caspase-1 is implicated in several important inflammatory diseases and controls adipocyte differentiation and insulin sensitivity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine and plays an important role in chronic inflammatory conditions. This study was planned to determine if there is any relationship between Caspase-1 and IL-10 levels in women with PCOS. Materials and methods: Forty-two women with PCOS and thirty-seven healthy controls were evaluated in this controlled clinical study. Caspase-1 and IL-10 levels, serum lipid sub-fractions, fasting glucose, fasting insulin and other hormones (gonadotropins, androgens), malondialdehyde (MDA) and glutathione (GSH) levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Results: Free androgen index (FAI), HOMA-IR, MDA and Caspase-1 levels were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower GSH concentration levels than healthy subjects. Serum IL-10 levels were higher in study subjects than in controls, though it was statistically insignificant. Caspase-1 was positively associated with IL-10. Conclusion: These outcomes propose that Caspase-1 may have a role in triggering the processes leading to chronic low-grade inflammation in women with PCOS, independent of insulin resistance, androgen excess and oxidative stress. Nevertheless, the precise role of Caspase-1 in the pathogenesis of the disease remains to be elucidated. (C) 2020 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. C1 [Cabus, Umit; Kabukcu, Cihan; Oztekin, Ozer; Fenkci, Veysel] Pamukkale Univ, Sch Med, Dept Obstet & Gynecol, Denizli, Turkey. [Fenkci, Semin] Pamukkale Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Denizli, Turkey. [Caner, Vildan] Pamukkale Univ, Sch Med, Dept Med Genet, Denizli, Turkey. [Enli, Yasar] Pamukkale Univ, Sch Med, Dept Biochem, Denizli, Turkey. |
| Databáze: | OpenAIRE |
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