Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats
| Autor: | Ewa Raczka, Miguel A. Quintana, Antonio Quintana |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
Diclofenac Indomethacin Hemodynamics Prostaglandin Vasodilation Pharmacology Hypercapnia chemistry.chemical_compound medicine Animals Chemistry Rats Inbred Strains Carbon Dioxide Rats respiratory tract diseases stomatognathic diseases medicine.anatomical_structure nervous system Cerebral blood flow Cerebrovascular Circulation Anesthesia cardiovascular system Arterial blood medicine.symptom circulatory and respiratory physiology Blood vessel medicine.drug |
| Zdroj: | European Journal of Pharmacology. 149:385-388 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(88)90674-7 |
| Popis: | Cerebral blood flow (CBF) was measured in conscious rats treated with indomethacin, diclofenac or the vehicle for indomethacin during hypercapnia of three different degrees. Similar values were found for CBF in rats treated with diclofenac or vehicle and there was a direct correlation between CBF and the arterial blood carbon dioxide values. In contrast, indomethacin completely blocked the increase of CBF during hypercapnia. These results suggest strongly that prostaglandins are not involved in the hypercapnia-induced cerebral vasodilatation. |
| Databáze: | OpenAIRE |
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