Selenium and thyroid cancer: a systematic review
| Autor: | Morgana Pinheiro Sousa, Luana Matos de Souza, Bruna Aparecida Melo Batista, Mônica de Oliveira Maia, Carla Soraya Costa Maia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty MEDLINE Thyroid Gland Medicine (miscellaneous) chemistry.chemical_element Antioxidants 03 medical and health sciences Selenium 0302 clinical medicine Internal medicine medicine Animals Humans Thyroid Neoplasms Thyroid cancer 030109 nutrition & dietetics Nutrition and Dietetics business.industry medicine.disease Cross-Sectional Studies chemistry 030220 oncology & carcinogenesis Case-Control Studies Observational study business |
| Zdroj: | Nutrition and cancer. 72(8) |
| ISSN: | 1532-7914 |
| Popis: | The aim of the study was to investigate the association between blood and tissue levels of selenium and thyroid cancer through a systematic review. We searched for observational studies written in English, Spanish, and Portuguese indexed in PubMed, LILACS, and Scielo without date restriction, that evaluated the association between selenium levels in whole-blood, serum, or plasma and/or thyroid tissue and thyroid cancer, both in individuals with cancer of thyroid as in healthy individuals. Then data were extracted and analyzed. Of the 570 articles identified, five cross-sectional studies were included in the review. In one study, lower concentrations of selenium were found in whole-blood (0.543 μg/ml) and in the thyroid (0.88 μg/g) of thyroid cancer patients compared to controls. Another study showed a decrease in serum selenium concentrations in patients with follicular carcinoma and papillary types (0.077 ± 0.021 μg/ml and 0.080 ± 0.020 μg/ml, respectively). On the other hand, other studies showed no difference in plasma selenium content or glutathione peroxidase activity among patients and healthy volunteers. The available evidence on this issue is inconclusive. Additional studies are needed to elucidate the association between serum and/or tissue levels of selenium and the development of thyroid cancer. |
| Databáze: | OpenAIRE |
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