Cytotoxicity of carboplatin on human glioblastoma cells is reduced by the concomitant exposure to an extremely low-frequency electromagnetic field (50 Hz, 70 G)

Autor:	Zeinab Akbarnejad, Yaser Masoumi-Ardakani, Mohsen Basiri, Meysam Ahmadi-Zeidabadi, Maryam Amiri, Marzie Esmaeeli, Hossein Eskandary
Rok vydání:	2018
Předmět:	0301 basic medicine Cell Survival medicine.medical_treatment Biophysics Medicine (miscellaneous) Antineoplastic Agents Apoptosis urologic and male genital diseases Carboplatin 03 medical and health sciences chemistry.chemical_compound Electromagnetic Fields 0302 clinical medicine Cell Line Tumor Humans Medicine Extremely low frequency Cytotoxicity Chemotherapy Caspase 3 urogenital system business.industry Cancer General Medicine medicine.disease female genital diseases and pregnancy complications nervous system diseases Gene Expression Regulation Neoplastic Radiation therapy 030104 developmental biology chemistry 030220 oncology & carcinogenesis Concomitant Cancer research Glioblastoma business
Zdroj:	Electromagnetic Biology and Medicine. 37:138-145
ISSN:	1536-8386 1536-8378
Popis:	Glioblastoma multiforme (GBM) is a malignant brain cancer that causes high mortality in patients. GBM responds weakly to the common cancer treatments such as chemotherapy and radiotherapy and even surgery. Carboplatin is an alkylating agent widely used to treat cancer. However, resistance to this drug is a common problem in its use in cancer treatment. Concomitant exposure to extremely low-frequency electromagnetic fields (ELF-EMFs) and carboplatin is one unexplored possibility for overcoming this resistance. Indeed, many lines of evidence show that EMF affects cancer cells and drug action. In this study, we evaluated the effect of concomitant administration of carboplatin and EMF (50 Hz, 70 G) and also concomitant administration of carboplatin and static magnetic field (SMF) (70 G) on human glioma cell line (U-87). The results showed that cotreatment reduced the efficiency of carboplatin in U-87 cells, by decreasing caspase-3 in comparison to drug groups. Overall, EMF reduced the apoptotic effect of carboplatin, possibly through a redox regulation mechanism. Therefore, we have to avoid coadministration of magnetic field (MF) and carboplatin in tumor area, because the MF decreased the toxicity of the drug. However, further studies are needed to reveal the action mechanism of this combination therapeutic method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f71cfe9207807b36065762d7d54ffe https://doi.org/10.1080/15368378.2018.1477052 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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