Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
| Autor: | Edward M. Gilbert, Barbara Johnson, Karleen S. Callahan, Ina J. Amber, Mark A. Munger |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Cardiomyopathy
Dilated Male medicine.medical_specialty medicine.medical_treatment Cardiac Output Low Myocardial Ischemia Enzyme-Linked Immunosorbent Assay Ventricular Function Left Proinflammatory cytokine Norepinephrine Internal medicine Idiopathic dilated cardiomyopathy medicine Humans Receptor Coronary sinus Exercise Tolerance business.industry Interleukin-6 Tumor Necrosis Factor-alpha Receptors Interleukin-2 Stroke Volume Arteries Middle Aged medicine.disease Coronary Vessels Cytokine Endocrinology Heart failure Etiology Cytokines Tumor necrosis factor alpha Female Inflammation Mediators Cardiology and Cardiovascular Medicine business Adrenergic alpha-Agonists Interleukin-1 |
| Zdroj: | The American journal of cardiology. 77(9) |
| ISSN: | 0002-9149 |
| Popis: | Proinflammatory cytokines are capable of modulating cardiovascular function by a variety of mechanisms. These cytokines are elevated in patients with severe heart failure, but changes in mild or moderate heart failure have not been reported. Therefore, simultaneous arterial and coronary sinus concentrations of interleukin-1alpha, soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha were measured in 78 patients with New York Heart Association functional class II to IV heart failure and compared with 17 healthy volunteers. Concentrations of interleukin-1alpha, soluble interleukin-2 receptor, and interleukin-6 were determined by a "sandwich" enzyme-linked immunosorbent assay and tumor necrosis factor-alpha by tissue culture technique. There were no statistical differences in interleukin-1alpha, soluble interleukin-2 receptor, or tumor necrosis factor-alpha concentrations in mild to moderate heart failure versus control subjects. Interleukin-6 was significantly elevated, 75 +/- 16 versus 0.4 +/- 0.4pg/ml (p = 0.002). Cytokine concentrations did not differ by heart failure etiology. Paired arterial and coronary sinus concentrations were not significantly different. Soluble interleukin-2 receptor concentrations were significantly correlated with New York Heart Association functional class (r = 0.59, p = 0.04) and negatively associated with exercise tolerance time (r = -0.59, p = 0.007). Thus, interleukin-6 is significantly elevated in mild or moderate heart failure. |
| Databáze: | OpenAIRE |
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