Donor hepatitis C seropositivity: clinical correlates and effect on early graft and patient survival in adult cadaveric kidney transplantation
| Autor: | Kent C. Holtzmuller, S. John Swanson, Thomas G. Peters, Kevin C. Abbott, Jay R. Bucci, Cal S. Matsumoto, Lawrence Y. Agodoa |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Hepacivirus Hepatitis C virus medicine.disease_cause Gastroenterology Cohort Studies Internal medicine medicine Cadaver Humans Serologic Tests Survival analysis Kidney transplantation Retrospective Studies Hepatitis biology business.industry Graft Survival General Medicine Hepatitis C Middle Aged biology.organism_classification medicine.disease Kidney Transplantation Survival Analysis Tissue Donors Surgery Transplantation Nephrology business Kidney disease |
| Zdroj: | Journal of the American Society of Nephrology : JASN. 13(12) |
| ISSN: | 1046-6673 |
| Popis: | The impact of hepatitis C virus-positive donor kidneys on patient survival has not been analyzed in a national study. This study analyzed 20,111 adult (age, > or =16 yr) recipients having solitary cadaveric kidney transplants from adult donors with valid donor hepatitis C serologies from July 1, 1994, to June 30, 1998, in an historical cohort study (the 2000 United States Kidney Data System) of patient survival. Analysis was by the Cox proportional hazards models, which corrected for characteristics thought to affect outcomes. Of 484 kidneys positive for hepatitis C virus serology, 165 (34%) were given to recipients with confirmed negative hepatitis C serologies. Unadjusted 3-yr patient survival was 93% in all recipients of donor hepatitis C-negative kidneys versus 85% in all recipients of donor hepatitis C-positive kidneys (P = 0.01). Among hepatitis C-positive recipients, those who received hepatitis C-positive kidneys had worse survival than recipients of hepatitis C-negative kidneys. Among elderly hepatitis C-negative recipients, those who received hepatitis C-positive kidneys also had worse survival; in fact, all recipients of donor hepatitis C-positive kidneys had increased risk of mortality (P = 0.028). There were no significant interactions between donor hepatitis C positivity and either recipient hepatitis C positivity or older recipient age. The use of hepatitis C-positive kidneys in recipients who were hepatitis C-negative was fairly common and contrary to some current recommendations. Recipients of donor hepatitis C-positive kidneys were at independently increased risk of mortality, with no evidence that any subgroups were less affected. |
| Databáze: | OpenAIRE |
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