Prognostic Impact of Epidermal Growth Factor Receptor Overexpression in Patients with Cervical Cancer: A Meta-Analysis

Autor: Kun Fang, Miao-Ling Huang, Qing Chen, Ping-Ling Wang, Wei-Jie Tian, Qing-Feng Qin
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Cancer Treatment
lcsh:Medicine
Uterine Cervical Neoplasms
Cervical Cancer
Database and Informatics Methods
0302 clinical medicine
Mathematical and Statistical Techniques
Medicine and Health Sciences
Epidermal growth factor receptor
Clinical Trials (Cancer Treatment)
Database Searching
lcsh:Science
Cervical cancer
Multidisciplinary
biology
Pharmaceutics
Hazard ratio
Antibodies
Monoclonal
Chemoradiotherapy
Prognosis
ErbB Receptors
Gene Expression Regulation
Neoplastic
030220 oncology & carcinogenesis
Meta-analysis
Lymphatic Metastasis
Physical Sciences
Carcinoma
Squamous Cell
Female
Anatomy
Statistics (Mathematics)
Research Article
Clinical Oncology
medicine.medical_specialty
Histology
Radiation Therapy
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Disease-Free Survival
03 medical and health sciences
Drug Therapy
Internal medicine
medicine
Chemotherapy
Humans
Statistical Methods
Gynecology
business.industry
lcsh:R
Cancers and Neoplasms
Biology and Life Sciences
Odds ratio
medicine.disease
Confidence interval
Clinical trial
030104 developmental biology
biology.protein
lcsh:Q
Clinical Medicine
business
Gynecological Tumors
Combination Chemotherapy
Mathematics
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 7, p e0158787 (2016)
ISSN: 1932-6203
Popis: Clinical trials have provided conflicting results regarding whether epidermal growth factor receptor (EGFR) overexpression predicts poor survival in cervical cancer patients. In this study, we perform a meta-analysis of the association between EGFR expression and survival in cervical cancer patients. We searched clinical studies in the Medline, PubMed, Embase, and Web of Science databases. A total of 22 studies with 2,505 patients were included, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for each study. Heterogeneity was assessed using Higgins I2 to select a Mantel-Haenszel fixed effects model (I2 ≤50%) or a DerSimonian-Laird random effects model (I2 ≥50%). High EGFR levels predicted poor overall survival (OS) (HR: 1.40, 95% CI: 1.10-1.78) and disease-free survival (DFS) (HR: 1.84, 95% CI: 1.51-2.24). Stratified analyses showed that EGFR overexpression was significantly related to poor DFS in patients treated with chemoradiation or surgery. Moreover, the pooled odds ratios (ORs) revealed associations between EGFR expression and clinicopathological features, such as lymph node metastasis (OR: 1.72, 95% CI: 1.23-2.40) and tumor size ≥4 cm (OR: 1.64, 95% CI: 1.20-2.23). This meta-analysis demonstrates that EGFR overexpression is closely associated with reduced survival in patients with cervical cancer. These results may facilitate the individualized management of clinical decisions for anti-EGFR therapies in cervical cancer patients.
Databáze: OpenAIRE
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