Serum dipeptidyl peptidase 4 activity in children with type 1 diabetes mellitus
| Autor: | Ryo Sumazaki, Tomohiro Kamoda, Atsushi Iwabuchi, Isho Izumi, Makoto Saito, Takeki Hirano, Hiroki Nozue |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Dipeptidyl Peptidase 4 Endocrinology Diabetes and Metabolism Endocrinology immune system diseases Internal medicine medicine Humans In patient Child Serum adiponectin Dipeptidyl peptidase-4 Glycemic Type 1 diabetes Adiponectin business.industry Dipeptidyl Peptidase-4 Activity nutritional and metabolic diseases Insulin sensitivity medicine.disease Diabetes Mellitus Type 1 Case-Control Studies Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 26 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2013-0122 |
| Popis: | BACKGROUND It is poorly understood whether dipeptidyl peptidase 4 (DPP4) activity is altered and how DPP4 contributes to glycemic control in patients with type 1 diabetes mellitus (T1DM). AIM The aim of this study was to measure serum DPP4 activity and to assess its relationships to metabolic variables in T1DM children. METHODS Serum DPP4 activity was determined using a fluorometric assay in 43 T1DM and 26 control children. RESULTS Serum DPP4 activity was significantly higher in T1DM children than in controls (3.57 ± 0.99 vs. 2.67 ± 0.77 U/mL, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|