| Autor: |
Masaru Tanioka, Tsugumi Ebihana, Manae Uraguchi, Haruka Shoji, Yuka Nakamura, Rina Ueda, Shota Ogura, Yoshifumi Wakiya, Tohru Obata, Takahiro Ida, Jun Horigome, Shinichiro Kamino |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
RSC Advances. 12:20714-20720 |
| ISSN: |
2046-2069 |
| DOI: |
10.1039/d2ra03534k |
| Popis: |
The fluorescence spectral fingerprint, also known as the excitation-emission matrix (EEM), is used to assess and visualize therapeutic drug photodegradation in combination with chemometrics. Examination of EEM-parallel factor analysis (PARAFAC) data showed that an individual component was easily separated from a mixture of photogenerated products of a heterocyclic pharmacophore, in this case, phenothiazine drugs (PTZs). Detailed investigations of both structure-EEM relationships and kinetics revealed that the components extracted from EEM-PARAFAC could be quantitatively attributed to such photogenerated products as phenothiazine sulfoxide and carbazole derivatives. EEM in combination with principal component analysis (PCA) could be used as a mapping tool to visualize information of the photodegradation process of PTZs. We also assessed the photostability of various types of PTZs containing side chains by using validated EEM-PARAFAC methodology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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