Long Term Results of Stanford V Regimen and Highly Active Antiretroviral Therapy (HAART) In 59 Patients (pts) with HD and HIV Infection (HD-HIV)
| Autor: | Renato Talamini, Emanuela Vaccher, Alessandro Re, Umberto Tirelli, Michele Spina, Salvatrice Mancuso, Clara Schiantarelli, Jean Gabarre |
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| Přispěvatelé: | Spina, M, Gabarre, J, Mancuso, S, Re, A, Schiantarelli, C, Talamini, R, Vaccher, E, Tirelli, U |
| Rok vydání: | 2010 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry medicine.medical_treatment Immunology Human immunodeficiency virus (HIV) Phases of clinical research Cell Biology Hematology Stanford V regimen Long term results chemotherapy medicine.disease_cause medicine.disease Biochemistry Settore MED/15 - Malattie Del Sangue Surgery Stanford V Idiopathic pneumonia syndrome Internal medicine Concomitant medicine Hodgkin's disease Fresh frozen plasma business |
| Zdroj: | Publons |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Abstract 4827 Background: The introduction of HAART has significantly improved the outcome of pts with HD-HIV. However there are no data on the long term follow-up of HD-HIV pts treated with conventional chemotherapy (CT) regimens. In 2002, we reported the results of a prospective phase II study with the intensive 12-week CT with adjuvant radiotherapy (Stanford V) and concomitant HAART in 59 pts (Spina et al. Blood 2002;100:1984-1988). Methods: To analyze the long term outcome of patients included in the Stanford V and HAART protocol. Results: The median follow-up is 67months (range 3–156 months The 5-yr overall survival (OS), freedom from progression (FFP), disease free survival and event free survival are 54%, 52%, 60% and 37%, respectively. The 5-year OS is significantly different in pts with an international prognostic score (IPS) >2 in comparison to that of pts with an IPS Conclusions: Our data confirm the long term efficacy of Stanford V regimen in combination with HAART in HD-HIV. However, Stanford V is significantly less effective in pts with IPS>2 and therefore new strategies be tested in this setting. Supported by AIRC and ISS grants. Disclosures: No relevant conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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