Prevalence of anal fistulas in Europe: Systematic literature reviews and population-based database analysis

Autor: Damián García-Olmo, Javaria Mona Khalid, Marc van Dijk, Gert Van Assche, Julián Panés, Suvi R.K. Hokkanen, Marie Paule Richard, Mary Carmen Diez, Ignacio Tagarro, Dimitri Bennett
Přispěvatelé: UAM. Departamento de Cirugía, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
030213 general clinical medicine
Pediatrics
Time Factors
Epidemiology
CLINICAL-COURSE
Prevalence
HEMORRHOIDECTOMY
Disease
Research & Experimental Medicine
PHENOTYPE
0302 clinical medicine
Quality of life
Recurrence
Pharmacology (medical)
Pharmacology & Pharmacy
Original Research
education.field_of_study
Incidence (epidemiology)
Incidence
NATIONWIDE PREVALENCE
General Medicine
IN-ANO
Middle Aged
CROHNS-DISEASE
Europe
Treatment Outcome
Medicine
Research & Experimental
030220 oncology & carcinogenesis
Female
Life Sciences & Biomedicine
Adult
Anal fistula
medicine.medical_specialty
Medicina
Population
CLASSIFICATION
Young Adult
03 medical and health sciences
medicine
MANAGEMENT
Humans
Rectal Fistula
education
Science & Technology
business.industry
medicine.disease
Quality of Life
Etiology
business
INFLAMMATORY-BOWEL-DISEASE
Zdroj: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Advances in Therapy
DOI: 10.1007/s12325-019-01117-y
Popis: Introduction: Despite the fact that perianal fistulas are associated with significant morbidity and impaired quality of life, their prevalence in Europe is unknown. The aim of this study was to estimate the prevalence of perianal fistulas in Europe, overall and according to etiology. Methods: Two independent literature reviews were performed using different search strategies to maximize the identification of potentially relevant studies. Data from relevant articles were used to estimate the prevalence of perianal fistulas in Europe. The robustness of the estimate was evaluated using data from a large population-based database from the UK. Results: A total of 26 studies provided epidemiological data on perianal fistulas, of which 16 provided suitable data to estimate the prevalence. Estimations using these data yielded a total prevalence of 1.69 per 10,000 population. Cryptoglandular infection and Crohn’s disease (CD) were the predominant etiologies, with prevalence rates at 0.86 and 0.76 per 10,000 population, respectively. Comparison of prevalence data from the UK population-based database with the European population resulted in a standardized prevalence estimate of all perianal fistulas of 1.83 per 10,000 population, confirming the robustness of the literaturebased estimate. Conclusion: Although in terms of incidence cryptoglandular fistulas were clearly predominant, the prevalence of fistulas in CD and cryptoglandular infection appeared more balanced. This is due to the longer duration and higher frequency of relapses of fistulas in CD. The estimated prevalence implies that perianal fistulas meet the criteria to be considered as a rare condition in Europe (prevalence less than 5 per 10,000 population).
This study was funded by Takeda Pharmaceutical U.S.A., Inc. and TiGenix SAU
Databáze: OpenAIRE
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