Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age
| Autor: | Karla J. Hutt, Monika Bakai, Amy Winship, Urooza C. Sarma, Seng H. Liew |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Ovulation
endocrine system media_common.quotation_subject Dacarbazine lcsh:Medicine Estrous Cycle Ovary Primary Ovarian Insufficiency Article Andrology Mice 03 medical and health sciences Follicle 0302 clinical medicine Ovarian Follicle Corpus Luteum medicine Animals Ovarian Reserve Ovarian reserve lcsh:Science media_common Estrous cycle 030219 obstetrics & reproductive medicine Multidisciplinary business.industry Reproduction lcsh:R Antral follicle 3. Good health Mice Inbred C57BL Fertility medicine.anatomical_structure 030220 oncology & carcinogenesis Female lcsh:Q Folliculogenesis business medicine.drug |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-24960-5 |
| Popis: | Dacarbazine is commonly administered for the treatment of cancers prevalent in reproductive age females. However, investigations of off-target effects of dacarbazine on the ovary are limited. We assessed the impact of dacarbazine on the ovarian reserve of primordial follicles, essential for fertility. Eight week and 6 month old C57BL/6 J mice were administered with dacarbazine or saline on day (d)0 and d7, then sacrificed after 12 hours (h), or 14d (n = 4–5/group). Follicle numbers, follicle density, serum AMH and corpora lutea were quantified and estrous cyclicity monitored. In reproductively young mice, dacarbazine did not affect primordial follicle numbers at 12 h, but resulted in a 36% reduction at 14d (p |
| Databáze: | OpenAIRE |
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