Reward Responsiveness in Patients with Opioid Use Disorder on Opioid Agonist Treatment: Role of Comorbid Chronic Pain
| Autor: | Samuel W. Stull, Karran A. Phillips, Daniel Agage, Patrick H. Finan, William J. Kowalczyk, Chung Jung Mun, Diego A. Pizzagalli, Kenzie L. Preston, David H. Epstein, Janelle E. Letzen |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
03 medical and health sciences 0302 clinical medicine Reward Internal medicine medicine Humans In patient Reward responsiveness business.industry Chronic pain Opioid use disorder General Medicine Opioid-Related Disorders Response bias medicine.disease Comorbidity Confidence interval 030227 psychiatry Analgesics Opioid Anesthesiology and Pain Medicine Standard error Neurology (clinical) Chronic Pain Psychology Psychiatry & Brain Neuroscience Section business 030217 neurology & neurosurgery |
| Zdroj: | Pain Med |
| ISSN: | 1526-4637 1526-2375 |
| Popis: | Objective Evidence suggests that blunted reward responsiveness may account for poor clinical outcomes in both opioid use disorder (OUD) and chronic pain. Understanding how individuals with OUD and comorbid chronic pain (OUD+CP) respond to rewards is, therefore, of clinical interest because it may reveal a potential point of behavioral intervention. Methods Patients with OUD (n = 28) and OUD+CP (n = 19) on opioid agonist treatment were compared on: 1) the Probabilistic Reward Task (an objective behavioral measure of reward response bias) and 2) ecological momentary assessment of affective responses to pleasurable events. Results Both the OUD and the OUD+CP groups evidenced an increase in reward response bias in the Probabilistic Reward Task. The rate of change in response bias across blocks was statistically significant in the OUD group (B = 0.06, standard error [SE] = 0.02, t = 3.92, P Conclusions Overall, findings across objective and subjective measures were mixed, necessitating follow-up with a larger sample. The results suggest that although there is a reward response bias in patients with OUD+CP treated with opioid agonist treatment relative to patients with OUD without CP, it is modest and does not appear to translate into patients’ responses to rewarding events as they unfold in daily life. |
| Databáze: | OpenAIRE |
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