Eradication of Penicillin-resistant Pneumococci in the Nasopharynx with Antibiotic Combinations Including Rifampicin: Experiences from the South Swedish Pneumococcal Intervention Project
| Autor: | Kristina E. M. Persson, Karl Ekdahl, Mirek Vejvoda, Torsten Holmdahl |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Penicillin Resistance Antibiotics Erythromycin Penicillins Drug resistance medicine.disease_cause Pneumococcal Infections Microbiology Nasopharynx Streptococcus pneumoniae medicine Humans Child Antibiotics Antitubercular Antibacterial agent Sweden General Immunology and Microbiology business.industry Clindamycin Infant Newborn Amoxicillin Infant Drug Resistance Microbial General Medicine Anti-Bacterial Agents Nasopharyngeal Diseases Infectious Diseases Child Preschool Carrier State Drug Therapy Combination Rifampin business Rifampicin medicine.drug |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 29:373-375 |
| ISSN: | 1651-1980 0036-5548 |
| Popis: | 39 children with prolonged nasopharyngeal carriage (48-328 days) of intermediately to highly penicillin-resistant pneumococci (PRP) were treated for 7 days with rifampicin in combination with amoxicillin (n = 18) erythromycin (n = 17) or clindamycin (n = 4), according to resistance pattern. In all children, except for 1 carrying a rifampicin-resistant strain, control cultures from the nasopharynx 1-2 weeks after the last antibiotic dosage, yielded no growth of PRP. In 2 brothers, PRP with the same serogroup and resistance pattern were found in nasopharynx 10 weeks after the antibiotic treatment. These preliminary findings indicate that antibiotic regimens including rifampicin are effective in eradicating nasopharyngeal carriage, but reappearance of the same strain may occur after several weeks. Such treatments should be given with caution due to the risk of selecting rifampicin-resistant strains. Further controlled studies are needed to determine the optimal combination of antibiotics and appropriate duration of therapy. |
| Databáze: | OpenAIRE |
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