GTS-21, A Mixed Nicotinic Receptor Agonist/Antagonist, Does Not Affect The Nicotine Cue
| Autor: | Frans van Haaren, William R. Kem, Stephen C. Haworth, Karen G. Anderson |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Agonist Nicotine alpha7 Nicotinic Acetylcholine Receptor Pyridines medicine.drug_class Clinical Biochemistry Nicotinic Antagonists Receptors Nicotinic Pharmacology Toxicology Benzylidene Compounds Biochemistry Anabasine Discrimination Learning Behavioral Neuroscience Alkaloids Discrimination Psychological GTS-21 In vivo medicine Animals Rats Long-Evans Nicotinic Agonists Receptor Biological Psychiatry Antagonist Azocines Rats Nicotinic agonist Generalization Stimulus Cues Self-administration Psychology Quinolizines medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 64:439-444 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(99)00054-4 |
| Popis: | VAN HAAREN, F., K. G. ANDERSON, S. C. HAWORTH AND W. R. KEM. GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue. PHARMACOL BIOCHEM BEHAV 64(2) 439–444, 1999.—Identification of nicotinic receptor subtypes involved in nicotine dependence is required for guiding the design of more selective antagonists capable of blocking the nicotine cue and nicotine self-administration. Due to the multiplicity of nicotinic receptors in the mammalian brain, selective agonists and antagonists are needed to assess the functional involvement of a particular subtype in vivo. Only recently have a few nicotinic receptor subtype-selective antagonists and agonists been identified. GTS-21 (also known as DMBX-anabaseine) is the only agent so far reported that selectively stimulates the α7 nicotinic receptor. Here GTS-21 was used to assess the possible mediation of the nicotine cue by this receptor subtype. Long–Evans rats were trained to discriminate between presession administration of 0.10 or 0.40 mg/kg (−)-nicotine bitartrate and its vehicle. GTS-21 did not substitute for nicotine, as all subjects consistently chose the vehicle lever after GTS-21 substitution. In another experiment, different doses of GTS-21 were administered prior to nicotine administration to investigate whether GTS-21 would antagonize the nicotine cue. Such was not the case. The lack of effect of GTS-21 upon the nicotine cue is consistent with the notion that the cue is mediated by nicotinic receptors other than the α7 receptor. |
| Databáze: | OpenAIRE |
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