Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis
| Autor: | Gunasekaran Sivagami, Arivalagan Sivaranjani, Namasivayam Nalini |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Antioxidant Carcinogenesis medicine.medical_treatment Pharmacology Antioxidants Lipid peroxidation chemistry.chemical_compound Subcutaneous injection 0302 clinical medicine Aberrant crypt foci Carvacrol chemistry.chemical_classification biology Glutathione peroxidase General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Catalase 1 2-Dimethylhydrazine Tumor Burden colon cancer Oncology 030220 oncology & carcinogenesis Colonic Neoplasms bacterial enzymes Colonic Polyps lcsh:RC254-282 Chemoprevention Superoxide dismutase 03 medical and health sciences medicine Animals Radiology Nuclear Medicine and imaging Glutathione Peroxidase business.industry Superoxide Dismutase Body Weight Rats Disease Models Animal 030104 developmental biology chemistry Immunology biology.protein Monoterpenes Cymenes Lipid Peroxidation business |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 12, Iss 2, Pp 755-762 (2016) |
| ISSN: | 1998-4138 |
| Popis: | Purpose: Colorectal cancer (CRC) is a leading cause for cancer-related death and its prevention is of great importance throughout the world. Chemoprevention offers a novel approach to control the incidence of colon cancer. The present study was performed to evaluate the efficacy of carvacrol supplementation on colonic aberrant crypt foci (ACF), lipid peroxidation, and antioxidant defense system in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats. Materials and Methods: The rats were randomly divided into six groups. Group 1, control rats received modified pellet diet; Group 2 rats received modified pellet diet along with carvacrol (80 mg/kg b.wt/day); Groups 3–6 received subcutaneous injection of DMH (20 mg/kg b.wt), once a week for the first 4 weeks; in addition Groups 4–6 received carvacrol at three different doses of 20, 40, and 80 mg/kg b.wt/day for 16 weeks. Results: Our result suggest that increased tumor incidence and increased number of ACF, increased bacterial enzymes accompanied by a decrease in the colonic lipid peroxidation, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were observed in DMH-treated rats. Administration of carvacrol to DMH-treated rats significantly decreased the tumor incidence and the number of ACF and bacterial enzymes with enhancement of colonic lipid peroxidation, GPx, SOD, and CAT activities. Conclusion: The results of this study suggest that carvacrol at a dose of 40 mg/kg b.wt showed a significant beneficial effect against chemically-induced colon carcinogenesis in rats. |
| Databáze: | OpenAIRE |
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