Multiple allelism at the locus controlling warfarin resistance in the Norway rat

Autor:	Priscilla Ayres, J. H. Greaves
Rok vydání:	1982
Předmět:	Genetics Drug Resistance Rats Inbred Strains Locus (genetics) General Medicine Multiple alleles Biology Major gene Rats symbols.namesake Species Specificity medicine Mendelian inheritance symbols Animals Warfarin resistance Warfarin medicine.symptom Alleles
Zdroj:	Genetical Research. 40:59-64
ISSN:	1469-5073 0016-6723
Popis:	SUMMARYTwo warfarin-resistant strains of the Norway rat, Rattus norvegicus, derived independently from wild populations in Wales and Scotland and both homozygous for a major gene at the warfarin-resistance locus, Rw, were found to differ in their hypoprothrombinaemic response to simultaneous dosage with warfarin and vitamin K. The Welsh strain gave a small response and the Scottish strain a large response. These two response levels segregated in Mendelian fashion in various crosses involving the two resistant strains and a third, non-resistant strain. This indicates that the Rw locus has a series of three multiple alleles, denoted Rww, Rws and Rw+. The results are discussed briefly in relation to biochemical, ecological and evolutionary aspects of warfarin resistance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e9b4a6ccd269959dcc3bdeeca655c2 https://doi.org/10.1017/s0016672300018905 Zobrazit plný text záznamu