Hypothyroidism as an Immune-Related Adverse Event Caused by Atezolizumab in a Patient with Muscle Spasms: A Case Report
| Autor: | Masanori Kawataki, Yosuke Nakanishi, Toshihide Yokoyama, Tadashi Ishida |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
History ICIs immune checkpoint inhibitors RC705-779 hyperCKemia TRAb Antithyrotropin receptor antibody Polymers and Plastics Immune checkpoint inhibitors (ICIs) fungi Immune-related adverse events (irAEs) Case Report nab-PTX nab-paclitaxel Hyperthyroidism CPK creatine phosphokinase TPO Ab Antithyroperoxidase antibody Industrial and Manufacturing Engineering irAEs immune-related adverse events Diseases of the respiratory system Hypothyroidism TSH thyroid stimulating hormone Muscle cramps Business and International Management |
| Zdroj: | Respiratory Medicine Case Reports Respiratory Medicine Case Reports, Vol 36, Iss, Pp 101585-(2022) |
| ISSN: | 1556-5068 |
| DOI: | 10.2139/ssrn.3984033 |
| Popis: | A 60-year-old man with a history of 4 cycles of atezolizumab treatment for non-small cell lung cancer presented to our hospital with a chief complaint of proximal muscle-dominant spasms. Blood tests showed elevated creatine phosphokinase (CPK) of 8450 U/L and hypothyroidism. There was little improvement even after stopping levetiracetam and pregabalin, and no subspinous physical findings of myositis. After levothyroxine was started for hypothyroidism, his muscle cramps and serum CPK level improved. Hypothyroidism as an immune-related adverse event can cause muscle spasms and is important in the differential diagnosis of muscle spasms in patients treated with immune checkpoint inhibitors. |
| Databáze: | OpenAIRE |
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