Resistance of certain leukaemic myeloblasts to immunological attack
| Autor: | I. C. M. Maclennan, J. Wood, D. G. L. Gale |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Cancer Research
biology medicine.medical_treatment Immunogenicity Bone Marrow Cells Rats Inbred Strains Complement System Proteins Immunotherapy Disease Cytotoxicity Tests Immunologic Rats Radiation Effects Leukemia Myeloid Acute Oncology Bone Marrow Antibody Formation Immunology biology.protein medicine Animals Humans Lymphocytes Antibody Acute myeloblastic leukaemia |
| Zdroj: | International Journal of Cancer. 15:995-999 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910150616 |
| Popis: | Leukaemic cells from four out of 19 patients with acute myeloblastic leukaemia are shown to be resistant to lysis by rat anti-muman-myeloblast antibody in the presence of complement. To a lesser degree this is reflected in lack of immunogenicity of these myeloblasts. It is suggested that these findings may be relevant in planning immunotherapy in this disease and evaluating the benefit of this type of treatment. Finally data are presented to show that loss of immunogenicity of myeloblasts after irradiation with 10,000 R, as is practised in certain immunotherapy schedules, is small compared with differences in immunogenicity between non-irradiated myeloblasts from different individuals. |
| Databáze: | OpenAIRE |
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