Fibulins and cancer: friend or foe?
| Autor: | William M. Gallagher, Linda C. Whelan, Caroline A. Currid |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Genetics
chemistry.chemical_classification Tumor Suppressor Proteins Alternative splicing Calcium-Binding Proteins Motility Cancer Angiogenesis Inhibitors Genetic Therapy Biology Cell morphology medicine.disease Growth Inhibitors Fibulin Cell biology Extracellular matrix Alternative Splicing chemistry Neoplasms medicine Molecular Medicine Humans Glycoprotein Molecular Biology Gene |
| Zdroj: | Trends in molecular medicine. 11(7) |
| ISSN: | 1471-4914 |
| Popis: | The fibulins are a family of secreted glycoproteins, which are characterised by repeated epidermal-growth-factor-like domains and a unique C-terminal structure. Six distinct fibulin genes, encoding at least nine protein products generated by alternative splicing, have been identified. Considerable evidence is available pointing towards a structural role for fibulins within the extracellular matrix. Fibulins have been shown to modulate cell morphology, growth, adhesion and motility. The dysregulation of certain fibulins occurs in a range of human disorders, including cancer. Indeed, both tumour suppressive and oncogenic activities have been proposed for members of the fibulin family. Herein, we discuss the possible roles of fibulins in cancer, in addition to their diagnostic and therapeutic potential. |
| Databáze: | OpenAIRE |
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