Basic amino acids and dimethylarginines targeted metabolomics discriminates primary hepatocarcinoma from hepatic colorectal metastases
| Autor: | Dominique Melck, Giuseppe Castello, Debora Paris, Rosa Calemma, Monica Gelzo, Oceania D'Apolito, Francesco Izzo, Andrea Motta, Daniela Garofalo, Gaetano Corso, Giuseppe Palmieri |
|---|---|
| Přispěvatelé: | D'Apolito, O., Garofalo, D., Gelzo, M., Paris, D., Melck, D., Calemma, R., Izzo, F., Palmieri, G., Castello, G., Motta, A., Corso, G. |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Arginine Colorectal cancer Endocrinology Diabetes and Metabolism Clinical Biochemistry Metastase Metastases Biology Tissue metabolic profiling Biochemistry Dimethylarginines Hepatic tumorigenesis Dimethylarginine Internal medicine medicine Hepatic tumorigenesi Intrahepatic Cholangiocarcinoma Mass spectrometry Basic amino acids Cancer medicine.disease Basic amino acid Molecular medicine digestive system diseases Endocrinology Hepatocellular carcinoma Biomarker (medicine) Differential diagnosis |
| Zdroj: | Metabolomics (Dordrecht. Print) (2014): 1–10. doi:10.1007/s11306-014-0641-2 info:cnr-pdr/source/autori:D'Apolito O.; Garofalo D.; Gelzo M.; Paris D.; Melck D.; Calemma R.; Izzo F.; Palmieri G.; Castello G.; Motta A.; Corso G./titolo:Basic amino acids and dimethylarginines targeted metabolomics discriminates primary hepatocarcinoma from hepatic colorectal metastases/doi:10.1007%2Fs11306-014-0641-2/rivista:Metabolomics (Dordrecht. Print)/anno:2014/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume |
| ISSN: | 1573-3890 1573-3882 |
| DOI: | 10.1007/s11306-014-0641-2 |
| Popis: | Hepatocellular carcinoma (HCC) is a very aggressive neoplasia requiring early and accurate diagnosis to improve patient outcomes with timely treatment. The liver is also very frequently colonized by metastases, and the most frequent differential diagnosis is HCC against intrahepatic cholangiocarcinoma or metastatic adenocarcinoma. Metabolomics is a powerful tool for identification of altered biomarkers in cancer, and to evaluate the efficacy of drug treatments. Here we analyzed by HILIC-MS/MS methylated arginines, basic amino acids (Arg, Cit, Orn), and their ratios in the extracts of primary HCC tissues, liver metastases from colorectal carcinoma (MET), cirrhotic related hepatitis-C-virus (CIR), and non-cirrhotic normal liver (NT) adjacent tissues. We found high levels of Arg (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|