Effects of pimobendan for mitral valve regurgitation in dogs
| Autor: | Hiroshi Kuse, Rui Kano, Nobuyuki Kanno, Yoshihide Sasaki, Masaya Kawasaki, Akashi Hara |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Hemodynamics Blood Pressure Renal Circulation Catecholamines Dogs Internal medicine Heart rate Renin medicine Animals Dog Diseases Aldosterone Mitral regurgitation Neurotransmitter Agents General Veterinary business.industry Mitral Valve Insufficiency Stroke volume medicine.disease Echocardiography Doppler Pyridazines Blood pressure Pimobendan Anesthesia Renal blood flow Cardiology Mitral valve regurgitation business Atrial Natriuretic Factor medicine.drug Glomerular Filtration Rate |
| Zdroj: | The Journal of veterinary medical science. 69(4) |
| ISSN: | 0916-7250 |
| Popis: | Pimobendan has a dual mechanism of action: it increases myocardial contractility by increasing calcium sensitization to troponin C and it promotes vasodilation by inhibiting PDEIII. This study examined the effects of pimobendan on cardiac function, hemodynamics, and neurohormonal factors in dogs with mild mitral regurgitation (MR). The dogs were given 0.25 mg/kg of pimobendan orally every 12 hr for 4 weeks. With pimobendan, the heart rate and stroke volume did not change, but the systolic blood pressure gradually decreased and the degree of mitral valve regurgitation tended to decrease. Renal blood flow was significantly increased and the glomerular filtration rate was slightly increased at 2 and 4 weeks. Furthermore, over the 4-week period, the plasma norepinephrine concentration decreased significantly, the systolic index increased slightly, the left atrial diameter and the left ventricular diameters decreased significantly, and the heart size improved. Given these results, pimobendan appears to be useful for treating MR in dogs. However, further long-term studies of pimobendan involving a larger number of dogs with mild and moderate MR are needed to establish the safety of pimobendan and document improvements in quality of life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|