Stress-related memories disrupt sociability and associated patterning of hippocampal activity: a role of hilar oxytocin receptor-positive interneurons
| Autor: | Mariah A.A. Meyer, Katsuhiko Nishimori, Max Anstötz, Lynn Y. Ren, Jelena Radulovic, Samantha Schroth, Ana Cicvaric, Viktoriya S. Grayson, Michael P. Fiske, Gianmaria Maccaferri, Anita L. Guedea |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Amnesia Male mice Hippocampal formation Molecular neuroscience Hippocampus Article lcsh:RC321-571 Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Interneurons Memory medicine Animals Humans Fear conditioning Receptor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Dentate gyrus Fear Oxytocin receptor Psychiatry and Mental health 030104 developmental biology Oxytocin Receptors Oxytocin Dentate Gyrus medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020) Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | In susceptible individuals, memories of stressful experiences can give rise to debilitating socio-affective symptoms. This occurs even when the ability to retrieve such memories is limited, as seen in patients suffering from traumatic amnesia. We therefore hypothesized that the encoding, rather than retrieval, mechanisms of stress-related memories underlie their impact on social and emotional behavior. To test this hypothesis, we used combinations of stress-enhanced and state-dependent fear conditioning, which engage different encoding mechanisms for the formation of stress-related memories. We found that the encoding of stress-enhanced state-dependent memories robustly and sex specifically impairs sociability in male mice and disrupts the asymmetry of dentate gyrus (DG)/CA3 activity accompanying social interactions. These deficits were restored by chemogenetic inactivation of oxytocin receptor-positive interneurons localized in the hilus (Oxtr-HI), and by inactivation of dorsohippocampal efferents to the caudal lateral septum. Together, our data suggest that disrupted patterning of dorsohippocampal DG/CA3 activity underlies stress-induced sociability deficits, and that Oxtr-HI can be a cellular target for improving these deficits. |
| Databáze: | OpenAIRE |
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