Metabolism of decoquinate in chickens and Japanese quail
| Autor: | R. B. Muntifering, M G Hayek, D R Catherman, D H Seman, R. E. Tucker, G. E. Mitchell, T Matsui, M L Westendorf, D B Batson, Cantor Ah |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
animal structures Coturnix Quail Excretion chemistry.chemical_compound Feces biology.animal Internal medicine medicine Animals Decoquinate Tissue Distribution Kidney biology General Medicine Metabolism Animal Feed Egg Yolk Wing vein Endocrinology medicine.anatomical_structure chemistry embryonic structures Hydroxyquinolines Animal Science and Zoology Female Chickens Clearance Half-Life |
| Zdroj: | Poultry science. 68(5) |
| ISSN: | 0032-5791 |
| Popis: | Thirty mature chicken hens and 40 mature Japanese quail hens were used in an experiment to compare pathways of decoquinate (DQ) excretion. Labelled DQ was injected into chickens (.5 μCi via wing vein puncture) and quail (.25 μCi via cardiac puncture) on Day 0. Blood was sampled at 0, 1.5, 3, 6, 9, 12, 24, and 48 h postinjectdon. Eggs and excreta of chickens and quail were collected for 28 and 14 days, respectively, and analyzed for 14 C. Six chickens and eight quail were sacrificed prior to 14 C-DQ injection and also on Days 1, 7, 14, and 34 or 32 postinjection. Samples of liver, heart, kidney, bile, skin, fat, and muscle were analyzed for 14 C. Blood rapidly cleared 14 C in both species, and the half-time of 14 C excretion via excreta was more rapid in quail (.37 day) than in chickens (.92 day). Little 14 C was found in the eggs of quail (.32% of dose) and chickens (.17% of dose). Quail appeared to excrete peak amounts of detectable 14 C 1 day earlier (Day 4) than chickens (Day 5). Liver contained the greatest concentration of 14 C on Day 1 in both species. By the end of the experiment, less than 1% of the dose remained in liver or other organs. Results indicate that chickens and quail metabolize 14 C-DQ at comparable rates and by similar pathways. |
| Databáze: | OpenAIRE |
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