Halothane Relaxes Previously Constricted Isolated Porcine Coronary Artery Segments More Than Isoflurane
| Autor: | Bruce Bollen, Kent Hermsmeyer, John H. Tinker |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Swine Vasodilation In Vitro Techniques Constriction chemistry.chemical_compound Internal medicine medicine Animals Porcine coronary artery Isoflurane business.industry Prostanoid Coronary Vessels Anesthesiology and Pain Medicine chemistry Vasoconstriction Anesthesia cardiovascular system Cardiology Halothane business medicine.drug |
| Zdroj: | Anesthesiology. 66:748-752 |
| ISSN: | 0003-3022 |
| Popis: | Coronary vasodilation by halothane and isoflurane were compared using in vitro tension recording. Porcine left anterior descending coronary arterial segments (1.5-2.0 mm o.d.) were constricted with either K+ (30 mM) or prostanoid U44069 (6 X 10(-7) M) in the absence of other drugs or anesthetics. Following stabilization of constriction, arteries were exposed to halothane or isoflurane at 0.5, 1.0, 1.5, 2.0, and 3.0% concentrations. K+ (30 mM) induced constriction was reduced by halothane at 1.5, 2.0, and 3.0% and U44069 (6 X 10(-7) M) induced constriction was reduced at 0.5, 1.0, 1.5, 2.0, and 3.0%. K+ (30 mM) induced constriction was reduced by isoflurane only at 3.0% and U44069 (6 X 10(-7) M) induced constriction was reduced by isoflurane only at 2.0 and 3.0%. U44069 induced constriction was more susceptible than K+ induced constriction to relaxation by halothane or isoflurane. Halothane was more potent than isoflurane as a direct relaxant of porcine epicardial left anterior descending arterial segments previously constricted with K+ (30 mM) or U44069 (6 X 10(-7) M). |
| Databáze: | OpenAIRE |
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