Parental age affects somatic mutation rates in the progeny of flowering plants
| Autor: | Ramamurthy Baskar, Viswanathan Gurumoorthy, Shanmuhapreya Dhanapal, Christian Sailer, Amit Kumar Singh, Anantha Maharasi Ramakrishnan, Ueli Grossniklaus, Tufail Bashir |
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| Přispěvatelé: | University of Zurich, Baskar, Ramamurthy |
| Rok vydání: | 2015 |
| Předmět: |
Physiology
Somatic cell Arabidopsis Cell Count Plant Science Flowers 580 Plants (Botany) Chromosomes Plant Frameshift mutation Germline mutation Meiosis 10126 Department of Plant and Microbial Biology 1311 Genetics Mutation Rate 1110 Plant Science Genetics Arabidopsis thaliana DNA Breaks Double-Stranded 10211 Zurich-Basel Plant Science Center Frameshift Mutation Recombination Genetic Ploidies biology Reproduction 1314 Physiology Articles biology.organism_classification Nondisjunction Seedlings Mutation (genetic algorithm) Mutation |
| Zdroj: | Plant physiology. 168(1) |
| ISSN: | 1532-2548 |
| Popis: | In humans, it is well known that the parental reproductive age has a strong influence on mutations transmitted to their progeny. Meiotic nondisjunction is known to increase in older mothers, and base substitutions tend to go up with paternal reproductive age. Hence, it is clear that the germinal mutation rates are a function of both maternal and paternal ages in humans. In contrast, it is unknown whether the parental reproductive age has an effect on somatic mutation rates in the progeny, because these are rare and difficult to detect. To address this question, we took advantage of the plant model system Arabidopsis (Arabidopsis thaliana), where mutation detector lines allow for an easy quantitation of somatic mutations, to test the effect of parental age on somatic mutation rates in the progeny. Although we found no significant effect of parental age on base substitutions, we found that frameshift mutations and transposition events increased in the progeny of older parents, an effect that is stronger through the maternal line. In contrast, intrachromosomal recombination events in the progeny decrease with the age of the parents in a parent-of-origin-dependent manner. Our results clearly show that parental reproductive age affects somatic mutation rates in the progeny and, thus, that some form of age-dependent information, which affects the frequency of double-strand breaks and possibly other processes involved in maintaining genome integrity, is transmitted through the gametes. |
| Databáze: | OpenAIRE |
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