P14.47 Tissue immune markers for central nervous system germinoma

Autor:	Zhi feng Shi, Keith W.K. Lo, A K Chan, Ching C. Lau, Ho Keung Ng
Rok vydání:	2019
Předmět:	Cancer Research Germinoma business.industry Central nervous system Human leukocyte antigen medicine.disease Poster Presentations medicine.anatomical_structure Oncology Tumor Escape HLA-A2 Antigen Immunology HLA-B Antigens medicine Immunohistochemistry Neurology (clinical) business Immunostaining
Zdroj:	Neuro Oncol
ISSN:	1523-5866 1522-8517
DOI:	10.1093/neuonc/noz126.282
Popis:	BACKGROUND Germinoma is the commonest CNS germ cell tumor. An important histological feature is prominent immune cell infiltrates. The composition of such immune cell infiltrates remains under-investigated in the literature. MATERIAL AND METHODS We collected a cohort of 40 cases of intra-cranial germinomas and examined the clinical and histopathological features. The tumor infiltrating immune cells were characterized by immunohistochemistry and image analysis. RESULTS Across the cohort, the mean positivity ± SE of CD3-positive T cell and CD20-positive B cells was 31.2% ± 3.1% and 15.2% ± 2.2%, respectively (p CONCLUSION Taken together, the predominant T cells infiltrate and PD-L1 expression suggest anti-PD-L1 therapeutic agents as potential novel treatment option for germinoma patients. The loss of HLA class I may represent one of the mechanisms for tumor immune escape in germinoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dea276308af21ef6612b816273da1e https://doi.org/10.1093/neuonc/noz126.282 Zobrazit plný text záznamu