[FREQUENCY OF OCCURRENCE OF POLYMORPHIC VARIANTS OF IL28B GENE AND GENOTYPES OF HEPATITIS C VIRUS IN POPULATION OF YAKUTIA: CLINICAL OUTCOMES]
| Autor: | S. I. Semenov, A. I. Fedorov, V. L. Osakovsky, S. S. Maksimova, F. A. Platonov |
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| Předmět: |
0301 basic medicine
gene polymorphism Hepatitis C virus Population Medicine (miscellaneous) Single-nucleotide polymorphism Biology medicine.disease_cause tt Microbiology 03 medical and health sciences interleukin 28b 0302 clinical medicine Genotype medicine genotype lb genotype 2 haplotype cc education Genotyping viral hepatitis c education.field_of_study General Medicine Virology QR1-502 030104 developmental biology Interleukin 28B 030211 gastroenterology & hepatology tg Gene polymorphism Viral load |
| Zdroj: | ResearcherID Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 0, Iss 2, Pp 86-92 (2017) |
| Popis: | Aim. Study clinical outcomes in patients with, chronic hepatitis C depending on genotype of hepatitis C virus (HCV) and IL28B gene polymorphism. Materials and methods. 592 individuals were examined, 75 of those had HCV RNAgenotypes determined by PCR. Genotyping of single nucleotide polymorphisms (SNP) - rs 12979860 (C/T) and rs8099917 (T/G) in IL28B gene was carried out by real-time PCR. Results. HCV RNA was detected in 72 examined residents of Yakutia. HCV lb genotype was determined in 74.2% of cases, 3a - in 11.4%, la and 2 - 5.7% each. Frequency of polymorph variant rsl2979860 CC was 72.2%, CT - 27.8%, rs8099917 TT - 61.1%, TG - 23.2%. Conclusion. Combination of HCV lb with polymorphic variants of IL28B gene rs.l.2979860 CC and rs8099917 CT showed a less aggressive course of the disease. On the other hand, HCV infection of individuals with genotype 3a and polymorphism rsl2979860 CC or rs809917 TT of IL28B gene showed a more severe clinical presentation. The presence of polymorph variants rs8099917 T/G and rs 12979860 C/T showed more severe clinical outcomes of HCV infection (viral load up to 19035212 copies, cirrhosis with ascite, hepatocarcinoma). |
| Databáze: | OpenAIRE |
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