Temperature Regulation in Depression: Functional 5HT1A Receptor Adaptation Differentiates Antidepressant Response
| Autor: | Katherine E Kasik, Stephen M. Stahl, Maria E. Johnson, Jeffrey L. Rausch |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Stimulation Serotonergic Sex Factors Internal medicine medicine Humans Pharmacology Analysis of Variance Depression Ipsapirone Area under the curve Hypothermia Adaptation Physiological Antidepressive Agents Psychiatry and Mental health Pyrimidines Endocrinology Receptor Serotonin 5-HT1A Antidepressant Female Analysis of variance Nortriptyline medicine.symptom Psychology Body Temperature Regulation medicine.drug |
| Zdroj: | Neuropsychopharmacology. 31:2274-2280 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/sj.npp.1301088 |
| Popis: | Observations in humans and animals have indicated that chronic, but not acute, antidepressant treatment (ADT) can desensitize 5-HT1A receptor-mediated responses, such as hypothermia. We hypothesized that 5-HT1A desensitization would be necessary for an antidepressant response (ADR) to occur. To test this hypothesis, we examined 5HT1A-agonist ipsapirone (IPS)-induced hypothermia in 28 depressed patients being treated with fixed doses of nortriptyline (75 mg) at 3-day and 3-week treatment points. Decreases in 24-item Hamilton scores (>12) were used to dichotomize the response data into ADR groups of 13 responders (ADR+) and 15 nonresponders (ADR-). A two-way repeated measures analysis of variance indicated significant temperature differences in the area under the curve between response groups across time from 3-day to 3-week intervals (df=1, 26, F=6.6, p |
| Databáze: | OpenAIRE |
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